Anti-ASGR1 Antibody (CAB6871)
- SKU:
- CAB6871
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-ASGR1 Antibody |
| 抗体コード: | CAB6871 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IHC |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-150 of human ASGR1 (NP_001662.1). |
| 申し込み: | WB IHC |
| 推奨希釈: | WB 1:1000 - 1:4000 IHC 1:50 - 1:200 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | HepG2, U-937, Mouse liver, Rat liver |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-150 of human ASGR1 (NP_001662.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MTKE YQDL QHLD NEES DHHQ LRKG PPPP QPLL QRLC SGPR LLLL SLGL SLLL LVVV CVIG SQNS QLQE ELRG LRET FSNF TAST EAQV KGLS TQGG NVGR KMKS LESQ LEKQ QKDL SEDH SSLL LHVK QFVS DLRS LSCQ MAAL QGNG SE |
| 遺伝子ID: | 432 |
| Uniprot: | P07306 |
| セルラーロケーション: | Membrane, Secreted, Single-pass type II membrane protein |
| 計算された分子量: | 29kDa/33kDa |
| 観察された分子量: | 39kDa |
| 同義語: | ASGR1, ASGPR, ASGPR1, CLEC4H1, HL-1 |
| バックグラウンド: | This gene encodes a subunit of the asialoglycoprotein receptor. This receptor is a transmembrane protein that plays a critical role in serum glycoprotein homeostasis by mediating the endocytosis and lysosomal degradation of glycoproteins with exposed terminal galactose or N-acetylgalactosamine residues. The asialoglycoprotein receptor may facilitate hepatic infection by multiple viruses including hepatitis B, and is also a target for liver-specific drug delivery. The asialoglycoprotein receptor is a hetero-oligomeric protein composed of major and minor subunits, which are encoded by different genes. The protein encoded by this gene is the more abundant major subunit. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. |
| UniProt Protein Function: | ASGR1: Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface. |
| UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 17p13.2 Cellular Component: integral to plasma membrane; extracellular region Molecular Function:protein binding; protein homodimerization activity; metal ion binding; asialoglycoprotein receptor activity; carbohydrate binding Biological Process: receptor-mediated endocytosis; cellular response to extracellular stimulus |
| NCBI Summary: | This gene encodes a subunit of the asialoglycoprotein receptor. This receptor is a transmembrane protein that plays a critical role in serum glycoprotein homeostasis by mediating the endocytosis and lysosomal degradation of glycoproteins with exposed terminal galactose or N-acetylgalactosamine residues. The asialoglycoprotein receptor may facilitate hepatic infection by multiple viruses including hepatitis B, and is also a target for liver-specific drug delivery. The asialoglycoprotein receptor is a hetero-oligomeric protein composed of major and minor subunits, which are encoded by different genes. The protein encoded by this gene is the more abundant major subunit. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011] |
| UniProt Code: | P07306 |
| NCBI GenInfo Identifier: | 308387363 |
| NCBI Gene ID: | 432 |
| NCBI Accession: | NP_001184145.1 |
| UniProt Secondary Accession: | P07306,I3L1X1, |
| UniProt Related Accession: | P07306 |
| Molecular Weight: | Observed MW: 39kDaCalculated MW: 29kDa/33kDa |
| NCBI Full Name: | asialoglycoprotein receptor 1 isoform b |
| NCBI Synonym Full Names: | asialoglycoprotein receptor 1 |
| NCBI Official Symbol: | ASGR1 |
| NCBI Official Synonym Symbols: | HL-1; ASGPR; ASGPR1; CLEC4H1 |
| NCBI Protein Information: | asialoglycoprotein receptor 1; hepatic lectin H1; C-type lectin domain family 4 member H1 |
| UniProt Protein Name: | Asialoglycoprotein receptor 1 |
| UniProt Synonym Protein Names: | C-type lectin domain family 4 member H1; Hepatic lectin H1; HL-1 |
| Protein Family: | Asialoglycoprotein receptor |
| UniProt Gene Name: | ASGR1 |
| UniProt Entry Name: | ASGR1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using ASGR1 antibody (CAB6871) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
 | Immunohistochemistry of paraffin-embedded human liver damage using ASGR1 antibody (CAB6871) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human colon carcinoma using ASGR1 antibody (CAB6871) at dilution of 1:100 (40x lens). |
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