Anti-ARL2BP Antibody (CAB15145)
- SKU:
- CAB15145
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-ARL2BP Antibody |
| 抗体コード: | CAB15145 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human |
| 宿主種: | Rabbit |
| 免疫原: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human ARL2BP (NP_036238.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human |
| ポジティブサンプル: | U-251MG, MCF7 |
| 免疫原: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human ARL2BP (NP_036238.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MDAL EGES FALS FSSA SDAE FDAV VGYL EDII MDDE FQLL QRNF MDKY YLEF EDTE ENKL IYTP IFNE YISL VEKY IEEQ LLQR IPEF NMAA FTTT LQHH |
| 遺伝子ID: | 23568 |
| Uniprot: | Q9Y2Y0 |
| セルラーロケーション: | Cytoplasm, Mitochondrion intermembrane space, Nucleus, centrosome, cilium basal body, cytoskeleton, microtubule organizing center, spindle |
| 計算された分子量: | 17kDa/18kDa |
| 観察された分子量: | 19kDa |
| 同義語: | ARL2BP, BART, BART1, RP66 |
| バックグラウンド: | ADP-ribosylation factor (ARF)-like proteins (ARLs) comprise a functionally distinct group of the ARF family of RAS-related GTPases. The protein encoded by this gene binds to ARL2.GTP with high affinity but does not interact with ARL2.GDP, activated ARF, or RHO proteins. The lack of detectable membrane association of this protein or ARL2 upon activation of ARL2 is suggestive of actions distinct from those of the ARFs. This protein is considered to be the first ARL2-specific effector identified, due to its interaction with ARL2.GTP but lack of ARL2 GTPase-activating protein activity. |
| UniProt Protein Function: | ARL2BP: Together with ARL2, plays a role in the nuclear translocation, retention and transcriptional activity of STAT3. May play a role as an effector of ARL2. Belongs to the ARL2BP family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:G protein regulator, misc.; Mitochondrial Chromosomal Location of Human Ortholog: 16q13 Cellular Component: centrosome; cytosol; midbody; mitochondrial intermembrane space; mitochondrial matrix Molecular Function:GTPase regulator activity; protein binding; transcription coactivator activity Biological Process: maintenance of protein localization in nucleus; positive regulation of tyrosine phosphorylation of STAT protein; regulation of insulin secretion; signal transduction Disease: Retinitis Pigmentosa With Or Without Situs Inversus |
| NCBI Summary: | ADP-ribosylation factor (ARF)-like proteins (ARLs) comprise a functionally distinct group of the ARF family of RAS-related GTPases. The protein encoded by this gene binds to ARL2.GTP with high affinity but does not interact with ARL2.GDP, activated ARF, or RHO proteins. The lack of detectable membrane association of this protein or ARL2 upon activation of ARL2 is suggestive of actions distinct from those of the ARFs. This protein is considered to be the first ARL2-specific effector identified, due to its interaction with ARL2.GTP but lack of ARL2 GTPase-activating protein activity. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9Y2Y0 |
| NCBI GenInfo Identifier: | 6912268 |
| NCBI Gene ID: | 23568 |
| NCBI Accession: | NP_036238.1 |
| UniProt Secondary Accession: | Q9Y2Y0,Q504R0, B3KQJ5, |
| UniProt Related Accession: | Q9Y2Y0 |
| Molecular Weight: | 46.2kD |
| NCBI Full Name: | ADP-ribosylation factor-like protein 2-binding protein |
| NCBI Synonym Full Names: | ADP ribosylation factor like GTPase 2 binding protein |
| NCBI Official Symbol: | ARL2BP |
| NCBI Official Synonym Symbols: | BART; RP66; BART1 |
| NCBI Protein Information: | ADP-ribosylation factor-like protein 2-binding protein |
| UniProt Protein Name: | ADP-ribosylation factor-like protein 2-binding protein |
| UniProt Synonym Protein Names: | Binder of ARF2 protein 1 |
| Protein Family: | ADP-ribosylation factor-like protein |
| UniProt Gene Name: | ARL2BP |
 | Western blot analysis of extracts of various cell lines, using ARL2BP antibody (CAB15145) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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