Anti-APBA2 Antibody (CAB16964)
- SKU:
- CAB16964
- Product type:
- Antibody
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
Frequently bought together:
Description
| 抗体名: | Anti-APBA2 Antibody |
| 抗体コード: | CAB16964 |
| 抗体サイズ: | 20uL, 50 uL |
| 申し込み: | WB |
| 反応性: | Rat |
| 宿主種: | Rabbit |
| 免疫原: | A synthetic peptide of Human APBA2. |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Rat |
| ポジティブサンプル: |
| 免疫原: | A synthetic peptide of Human APBA2. |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | Email for sequence |
| 遺伝子ID: | 321 |
| Uniprot: | Q99767 |
| セルラーロケーション: | |
| 計算された分子量: | 81kDa/82kDa |
| 観察された分子量: | Refer to figures |
| 同義語: | APBA2, D15S1518E, HsT16821, LIN-10, MGC:14091, MINT2, X11-BETA, X11L |
| バックグラウンド: | The protein encoded by this gene is a member of the X11 protein family. It is a neuronal adapter protein that interacts with the Alzheimer's disease amyloid precursor protein (APP). It stabilizes APP and inhibits production of proteolytic APP fragments including the A beta peptide that is deposited in the brains of Alzheimer's disease patients. This gene product is believed to be involved in signal transduction processes. It is also regarded as a putative vesicular trafficking protein in the brain that can form a complex with the potential to couple synaptic vesicle exocytosis to neuronal cell adhesion. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Protein Function: | APBA2: Putative function in synaptic vesicle exocytosis by binding to STXBP1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the beta-amyloid precursor protein (APP) and hence formation of beta-APP. Part of a multimeric complex containing STXBP1 and syntaxin-1. Binds to the cytoplasmic domain of amyloid protein beta, and to the nuclear factor NF-kappa-B/p65 via its PDZ domain. Interacts with the N-terminal domain of APBA2BP. Brain. |
| UniProt Protein Details: | Protein type:Adaptor/scaffold Chromosomal Location of Human Ortholog: 15q11-q12 Molecular Function:protein binding Biological Process: nervous system development |
| NCBI Summary: | The protein encoded by this gene is a member of the X11 protein family. It is a neuronal adapter protein that interacts with the Alzheimer's disease amyloid precursor protein (APP). It stabilizes APP and inhibits production of proteolytic APP fragments including the A beta peptide that is deposited in the brains of Alzheimer's disease patients. This gene product is believed to be involved in signal transduction processes. It is also regarded as a putative vesicular trafficking protein in the brain that can form a complex with the potential to couple synaptic vesicle exocytosis to neuronal cell adhesion. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q99767 |
| NCBI GenInfo Identifier: | 6226950 |
| NCBI Gene ID: | 321 |
| NCBI Accession: | Q99767.3 |
| UniProt Secondary Accession: | Q99767,O60571, Q5XKC0, E9PGI4, |
| UniProt Related Accession: | Q99767 |
| Molecular Weight: | 81,129 Da |
| NCBI Full Name: | Amyloid beta A4 protein-binding family A member 2 |
| NCBI Synonym Full Names: | amyloid beta precursor protein binding family A member 2 |
| NCBI Official Symbol: | APBA2 |
| NCBI Official Synonym Symbols: | X11L; MINT2; LIN-10; HsT16821; X11-BETA; D15S1518E; MGC:14091 |
| NCBI Protein Information: | amyloid beta A4 precursor protein-binding family A member 2 |
| UniProt Protein Name: | Amyloid beta A4 precursor protein-binding family A member 2 |
| UniProt Synonym Protein Names: | Adapter protein X11beta; Neuron-specific X11L protein; Neuronal Munc18-1-interacting protein 2; Mint-2 |
| Protein Family: | Amyloid beta A4 precursor protein-binding family |
| UniProt Gene Name: | APBA2 |
| UniProt Entry Name: | APBA2_HUMAN |