Anti-AP3M1 Antibody (CAB10410)
- SKU:
- CAB10410
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Frequently bought together:
Description
| 抗体名: | Anti-AP3M1 Antibody |
| 抗体コード: | CAB10410 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 219-418 of human AP3M1 (NP_036227.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | 22Rv1, Mouse liver, Mouse kidney, Rat spinal cord, Rat liver |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 219-418 of human AP3M1 (NP_036227.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | SLSF MNPR LLDD VSFH PCIR FKRW ESER VLSF IPPD GNFR LISY RVSS QNLV AIPV YVKH SISF KENS SCGR FDIT IGPK QNMG KTIE GITV TVHM PKVV LNMN LTPT QGSY TFDP VTKV LTWD VGKI TPQK LPSL KGLV NLQS GAPK PEEN PSLN IQFK IQQL AISG LKVN RLDM YGEK YKPF KGVK YVTK AGKF QVRT |
| 遺伝子ID: | 26985 |
| Uniprot: | Q9Y2T2 |
| セルラーロケーション: | Cytoplasmic side, Cytoplasmic vesicle membrane, Golgi apparatus, Peripheral membrane protein |
| 計算された分子量: | 46kDa |
| 観察された分子量: | 47kDa |
| 同義語: | AP3M1 |
| バックグラウンド: | The protein encoded by this gene is the medium subunit of AP-3, which is an adaptor-related protein complex associated with the Golgi region as well as more peripheral intracellular structures. AP-3 facilitates the budding of vesicles from the Golgi membrane, and it may directly function in protein sorting to the endosomal/lysosomal system. AP-3 is a heterotetrameric protein complex composed of two large subunits (delta and beta3), a medium subunit (mu3), and a small subunit (sigma 3). Mutations in one of the large subunits of AP-3 have been associated with the Hermansky-Pudlak syndrome, a genetic disorder characterized by defective lysosome-related organelles. Alternative splicing of this gene results in multiple transcript variants. |
| UniProt Protein Function: | AP3M1: Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. Belongs to the adaptor complexes medium subunit family. |
| UniProt Protein Details: | Protein type:Adaptor/scaffold Chromosomal Location of Human Ortholog: 10q22.2 Cellular Component: lysosomal membrane; lysosome Molecular Function:protein binding; Rab GTPase binding Biological Process: anterograde axon cargo transport; anterograde synaptic vesicle transport; protein targeting to lysosome |
| NCBI Summary: | The protein encoded by this gene is the medium subunit of AP-3, which is an adaptor-related protein complex associated with the Golgi region as well as more peripheral intracellular structures. AP-3 facilitates the budding of vesicles from the Golgi membrane, and it may directly function in protein sorting to the endosomal/lysosomal system. AP-3 is a heterotetrameric protein complex composed of two large subunits (delta and beta3), a medium subunit (mu3), and a small subunit (sigma 3). Mutations in one of the large subunits of AP-3 have been associated with the Hermansky-Pudlak syndrome, a genetic disorder characterized by defective lysosome-related organelles. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2016] |
| UniProt Code: | Q9Y2T2 |
| NCBI GenInfo Identifier: | 13123952 |
| NCBI Gene ID: | 26985 |
| NCBI Accession: | Q9Y2T2.1 |
| UniProt Secondary Accession: | Q9Y2T2,Q5JQ12, Q9H5L2, |
| UniProt Related Accession: | Q9Y2T2 |
| Molecular Weight: | 46,939 Da |
| NCBI Full Name: | AP-3 complex subunit mu-1 |
| NCBI Synonym Full Names: | adaptor related protein complex 3 mu 1 subunit |
| NCBI Official Symbol: | AP3M1 |
| NCBI Protein Information: | AP-3 complex subunit mu-1 |
| UniProt Protein Name: | AP-3 complex subunit mu-1 |
| UniProt Synonym Protein Names: | AP-3 adaptor complex mu3A subunit; Adaptor-related protein complex 3 subunit mu-1; Mu-adaptin 3A; Mu3A-adaptin |
| Protein Family: | AP-3 complex |
| UniProt Gene Name: | AP3M1 |
| UniProt Entry Name: | AP3M1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using AP3M1 antibody (CAB10410) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90s. |
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