Anti-ANTXR1 Antibody (CAB6525)
- SKU:
- CAB6525
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-ANTXR1 Antibody |
| 抗体コード: | CAB6525 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IF |
| 反応性: | Human, Mouse |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 84-333 of human ANTXR1 (NP_060623.2). |
| 申し込み: | WB IF |
| 推奨希釈: | WB 1:500 - 1:2000 IF 1:50 - 1:100 |
| 反応性: | Human, Mouse |
| ポジティブサンプル: | NCI-H460, HeLa, Mouse ovary, Mouse spleen |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 84-333 of human ANTXR1 (NP_060623.2). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | VFST RGTT LMKL TEDR EQIR QGLE ELQK VLPG GDTY MHEG FERA SEQI YYEN RQGY RTAS VIIA LTDG ELHE DLFF YSER EANR SRDL GAIV YCVG VKDF NETQ LARI ADSK DHVF PVND GFQA LQGI IHSI LKKS CIEI LAAE PSTI CAGE SFQV VVRG NGFR HARN VDRV LCSF KIND SVTL NEKP FSVE DTYL LCPA PILK EVGM KAAL QVSM NDGL SFIS SSVI ITTT HCSL HKIA SGPT TAAC ME |
| 遺伝子ID: | 84168 |
| Uniprot: | Q9H6X2 |
| セルラーロケーション: | Cell membrane, Cell projection, Single-pass type I membrane protein, filopodium membrane, lamellipodium membrane |
| 計算された分子量: | 33kDa/37kDa/39kDa/41kDa/59kDa/62kDa |
| 観察された分子量: | 75kDa |
| 同義語: | ANTXR1, ATR, GAPO, TEM8 |
| バックグラウンド: | This gene encodes a type I transmembrane protein and is a tumor-specific endothelial marker that has been implicated in colorectal cancer. The encoded protein has been shown to also be a docking protein or receptor for Bacillus anthracis toxin, the causative agent of the disease, anthrax. The binding of the protective antigen (PA) component, of the tripartite anthrax toxin, to this receptor protein mediates delivery of toxin components to the cytosol of cells. Once inside the cell, the other two components of anthrax toxin, edema factor (EF) and lethal factor (LF) disrupt normal cellular processes. Three alternatively spliced variants that encode different protein isoforms have been described. |
| UniProt Protein Function: | ANTXR1: Plays a role in cell attachment and migration. Interacts with extracellular matrix proteins and with the actin cytoskeleton. Mediates adhesion of cells to type 1 collagen and gelatin, reorganization of the actin cytoskeleton and promotes cell spreading. Plays a role in the angiogenic response of cultured umbilical vein endothelial cells. Defects in ANTXR1 are associated with susceptibility to hemangioma capillary infantile (HCI). HCI are benign, highly proliferative lesions involving aberrant localized growth of capillary endothelium. They are the most common tumor of infancy, occurring in up to 10% of all births. Hemangiomas tend to appear shortly after birth and show rapid neonatal growth for up to 12 months characterized by endothelial hypercellularity and increased numbers of mast cells. This phase is followed by slow involution at a rate of about 10% per year and replacement by fibrofatty stroma. Belongs to the ATR family. 4 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Actin-binding; Receptor, misc. Chromosomal Location of Human Ortholog: 2p13.1 Cellular Component: filopodium membrane; cell surface; plasma membrane; integral to membrane; endosome membrane Molecular Function:collagen binding; actin filament binding; protein binding; transmembrane receptor activity; metal ion binding Biological Process: actin cytoskeleton reorganization; reproductive process; pathogenesis; signal transduction Disease: Gapo Syndrome; Hemangioma, Capillary Infantile |
| NCBI Summary: | This gene encodes a type I transmembrane protein and is a tumor-specific endothelial marker that has been implicated in colorectal cancer. The encoded protein has been shown to also be a docking protein or receptor for Bacillus anthracis toxin, the causative agent of the disease, anthrax. The binding of the protective antigen (PA) component, of the tripartite anthrax toxin, to this receptor protein mediates delivery of toxin components to the cytosol of cells. Once inside the cell, the other two components of anthrax toxin, edema factor (EF) and lethal factor (LF) disrupt normal cellular processes. Three alternatively spliced variants that encode different protein isoforms have been described. [provided by RefSeq, Oct 2008] |
| UniProt Code: | Q9H6X2 |
| NCBI GenInfo Identifier: | 17366074 |
| NCBI Gene ID: | 84168 |
| NCBI Accession: | Q9H6X2.2 |
| UniProt Secondary Accession: | Q9H6X2,Q4ZFV6, Q53QD8, Q96P02, Q9NVP3, A8K7U8, J7K7G4 J7KF88, |
| UniProt Related Accession: | Q9H6X2 |
| Molecular Weight: | 564 |
| NCBI Full Name: | Anthrax toxin receptor 1 |
| NCBI Synonym Full Names: | anthrax toxin receptor 1 |
| NCBI Official Symbol: | ANTXR1 |
| NCBI Official Synonym Symbols: | ATR; GAPO; TEM8 |
| NCBI Protein Information: | anthrax toxin receptor 1; 2310008J16Rik; 2810405N18Rik; tumor endothelial marker 8 |
| UniProt Protein Name: | Anthrax toxin receptor 1 |
| UniProt Synonym Protein Names: | Tumor endothelial marker 8 |
| Protein Family: | Anthrax toxin receptor |
| UniProt Gene Name: | ANTXR1 |
| UniProt Entry Name: | ANTR1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using ANTXR1 antibody (CAB6525) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
 | Immunofluorescence analysis of MCF7 cells using ANTXR1 antibody (CAB6525). Blue: DAPI for nuclear staining. |
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