Anti-AMHR2 Antibody (CAB6523)
- SKU:
- CAB6523
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-AMHR2 Antibody |
| 抗体コード: | CAB6523 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 18-149 of human AMHR2 (NP_065434.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | Mouse lung, Rat kidney |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 18-149 of human AMHR2 (NP_065434.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | PPNR RTCV FFEA PGVR GSTK TLGE LLDT GTEL PRAI RCLY SRCC FGIW NLTQ DRAQ VEMQ GCRD SDEP GCES LHCD PSPR AHPS PGST LFTC SCGT DFCN ANYS HLPP PGSP GTPG SQGP QAAP GESI WMAL |
| 遺伝子ID: | 269 |
| Uniprot: | Q16671 |
| セルラーロケーション: | Membrane, Single-pass type I membrane protein |
| 計算された分子量: | 51kDa/52kDa/62kDa |
| 観察された分子量: | 58-63kDa |
| 同義語: | AMHR2, AMHR, MISR2, MISRII, MRII |
| バックグラウンド: | This gene encodes the receptor for the anti-Mullerian hormone (AMH) which, in addition to testosterone, results in male sex differentiation. AMH and testosterone are produced in the testes by different cells and have different effects. Testosterone promotes the development of male genitalia while the binding of AMH to the encoded receptor prevents the development of the mullerian ducts into uterus and Fallopian tubes. Mutations in this gene are associated with persistent Mullerian duct syndrome type II. Alternatively spliced transcript variants encoding different isoforms have been identified. |
| UniProt Protein Function: | MISR2: On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for anti-Muellerian hormone. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Kinase, protein; Protein kinase, Ser/Thr (receptor); Protein kinase, TKL; EC 2.7.11.30; TKL group; STKR family; Type2 subfamily Chromosomal Location of Human Ortholog: 12q13 Molecular Function:hormone binding; protein binding; receptor activity Biological Process: sex differentiation; signal transduction Disease: Persistent Mullerian Duct Syndrome, Types I And Ii |
| NCBI Summary: | This gene encodes the receptor for the anti-Mullerian hormone (AMH) which, in addition to testosterone, results in male sex differentiation. AMH and testosterone are produced in the testes by different cells and have different effects. Testosterone promotes the development of male genitalia while the binding of AMH to the encoded receptor prevents the development of the mullerian ducts into uterus and Fallopian tubes. Mutations in this gene are associated with persistent Mullerian duct syndrome type II. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Sep 2009] |
| UniProt Code: | Q16671 |
| NCBI GenInfo Identifier: | 9087133 |
| NCBI Gene ID: | 269 |
| NCBI Accession: | Q16671.1 |
| UniProt Secondary Accession: | Q16671,Q13762, Q647K2, A0AVE1, B9EGB7, E9PGD2, F8W1D2 |
| UniProt Related Accession: | Q16671 |
| Molecular Weight: | 51,827 Da |
| NCBI Full Name: | Anti-Muellerian hormone type-2 receptor |
| NCBI Synonym Full Names: | anti-Mullerian hormone receptor type 2 |
| NCBI Official Symbol: | AMHR2 |
| NCBI Official Synonym Symbols: | AMHR; MRII; MISR2; MISRII |
| NCBI Protein Information: | anti-Muellerian hormone type-2 receptor |
| UniProt Protein Name: | Anti-Muellerian hormone type-2 receptor |
| UniProt Synonym Protein Names: | Anti-Muellerian hormone type II receptor; AMH type II receptor; MIS type II receptor; MISRII; MRII |
| Protein Family: | Anti-Muellerian hormone type-2 receptor |
| UniProt Gene Name: | AMHR2 |
| UniProt Entry Name: | AMHR2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using AMHR2 antibody (CAB6523) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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