Anti-ALPI Antibody (CAB6226)
- SKU:
- CAB6226
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-ALPI Antibody |
| 抗体コード: | CAB6226 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 20-240 of human ALPI (NP_001622.2). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human |
| ポジティブサンプル: | HepG2 |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 20-240 of human ALPI (NP_001622.2). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | VIPA EEEN PAFW NRQA AEAL DAAK KLQP IQKV AKNL ILFL GDGL GVPT VTAT RILK GQKN GKLG PETP LAMD RFPY LALS KTYN VDRQ VPDS AATA TAYL CGVK ANFQ TIGL SAAA RFNQ CNTT RGNE VISV MNRA KQAG KSVG VVTT TRVQ HASP AGTY AHTV NRNW YSDA DMPA SARQ EGCQ DIAT QLIS NMDI DVIL GGGR KYMF PMGT PDPE YPAD A |
| 遺伝子ID: | 248 |
| Uniprot: | P09923 |
| セルラーロケーション: | Cell membrane, GPI-anchor, Lipid-anchor |
| 計算された分子量: | 56kDa |
| 観察された分子量: | 72kDa |
| 同義語: | ALPI, IAP |
| バックグラウンド: | There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The intestinal alkaline phosphatase gene encodes a digestive brush-border enzyme. This enzyme is a component of the gut mucosal defense system and is thought to function in the detoxification of lipopolysaccharide, and in the prevention of bacterial translocation in the gut. |
| UniProt Protein Function: | ALPI: intestinal alkaline phosphatase is one of four related alkaline phosphatases. The exact physiological function of alkaline phosphatases is not known. This protein is a GPI-anchored membrane bound glycosylated enzyme that is localized to fetal and adult intestines. |
| UniProt Protein Details: | Protein type:Cofactor and Vitamin Metabolism - folate biosynthesis; Motility/polarity/chemotaxis; Membrane protein, GPI anchor; Phosphatase; EC 3.1.3.1 Chromosomal Location of Human Ortholog: 2q37.1 Molecular Function:alkaline phosphatase activity; magnesium ion binding; protease binding; protein binding; zinc ion binding Biological Process: dephosphorylation |
| NCBI Summary: | There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The intestinal alkaline phosphatase gene encodes a digestive brush-border enzyme. This enzyme is a component of the gut mucosal defense system and is thought to function in the detoxification of lipopolysaccharide, and in the prevention of bacterial translocation in the gut. [provided by RefSeq, Dec 2014] |
| UniProt Code: | P09923 |
| NCBI GenInfo Identifier: | 130744 |
| NCBI Gene ID: | 248 |
| NCBI Accession: | P09923.2 |
| UniProt Secondary Accession: | P09923,Q53S80, Q9UBV5, Q9UCL2, B2R7Y4, |
| UniProt Related Accession: | P09923 |
| Molecular Weight: | 56,812 Da |
| NCBI Full Name: | Intestinal-type alkaline phosphatase |
| NCBI Synonym Full Names: | alkaline phosphatase, intestinal |
| NCBI Official Symbol: | ALPI |
| NCBI Official Synonym Symbols: | IAP |
| NCBI Protein Information: | intestinal-type alkaline phosphatase |
| UniProt Protein Name: | Intestinal-type alkaline phosphatase |
| Protein Family: | Intestinal-type alkaline phosphatase |
| UniProt Gene Name: | ALPI |
| UniProt Entry Name: | PPBI_HUMAN |
 | Western blot analysis of extracts of HepG2 cells, using ALPI Antibody (CAB6226) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
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