Anti-ALOX5 Antibody (RACO0454)
- SKU:
- RACO0454
- Product type:
- Recombinant Antibody
- Reactivity:
- Human
- Host Species:
- Human
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Conjugation:
- Unconjugated
Frequently bought together:
Description
| 商品名: | ALOX5 Antibody |
| Product SKU: | RACO0454 |
| サイズ: | 50ul |
| 宿主種: | Homo sapiens (Human) |
| 申し込み: | ELISA, IHC |
| 推奨される希釈: | IHC:1:50-1:200 |
| 反応性: | Human |
| 免疫原: | A synthesized peptide derived from human 5 Lipoxygenase |
| 憲法: | Liquid |
| ストレージバッファ: | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| 精製方法: | Affinity-chromatography |
| 抗体のクローン性: | Monoclonal |
| アイソタイプ: | Rabbit IgG |
| Conjugate: | Non-conjugated |
| バックグラウンド: | Catalyzes the first step in leukotriene biosynthesis, and thereby plays a role in inflammatory processes. |
| シノニム: | Arachidonate 5-lipoxygenase (5-LO) (5-lipoxygenase) (EC 1.13.11.34), ALOX5, LOG5 |
 | IHC image of RACO0454 diluted at 1:100 and staining in paraffin-embedded human spleen tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB. |
 | IHC image of RACO0454 diluted at 1:100 and staining in paraffin-embedded human lung tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB. |
| UniProt Protein Function: | 5-LO: arachidonate 5-lipoxygenase. Arachidonic acid promotes its phosphorylation by p38 MAPK-regulated MAPKAP kinases. Upregulated in glioblastoma multiforme and colon, pancreatic and bladder cancer. |
| UniProt Protein Details: | Protein type:Lipid Metabolism - linoleic acid; Nuclear envelope; EC 1.13.11.34; Oxidoreductase; Lipid Metabolism - arachidonic acid Chromosomal Location of Human Ortholog: 10q11.2 Cellular Component: extracellular space; nuclear membrane; nuclear matrix; nuclear envelope lumen; nuclear envelope; cytosol Molecular Function:protein binding; iron ion binding; arachidonate 5-lipoxygenase activity Biological Process: leukotriene biosynthetic process; leukotriene production during acute inflammatory response; lipoxygenase pathway; arachidonic acid metabolic process; leukotriene metabolic process Disease: Asthma, Susceptibility To |
| NCBI Summary: | This gene encodes a member of the lipoxygenase gene family and plays a dual role in the synthesis of leukotrienes from arachidonic acid. The encoded protein, which is expressed specifically in bone marrow-derived cells, catalyzes the conversion of arachidonic acid to 5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid, and further to the allylic epoxide 5(S)-trans-7,9-trans-11,14-cis-eicosatetrenoic acid (leukotriene A4). Leukotrienes are important mediators of a number of inflammatory and allergic conditions. Mutations in the promoter region of this gene lead to a diminished response to antileukotriene drugs used in the treatment of asthma and may also be associated with atherosclerosis and several cancers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012] |
| UniProt Code: | P09917 |
| NCBI GenInfo Identifier: | 126407 |
| NCBI Gene ID: | 240 |
| NCBI Accession: | P09917.2 |
| UniProt Secondary Accession: | P09917,Q5JQ14, B7ZLS0, E5FPY5, E5FPY7, E5FPY8, |
| UniProt Related Accession: | P09917 |
| Molecular Weight: | 674 |
| NCBI Full Name: | Arachidonate 5-lipoxygenase |
| NCBI Synonym Full Names: | arachidonate 5-lipoxygenase |
| NCBI Official Symbol: | ALOX5 |
| NCBI Official Synonym Symbols: | 5-LO; 5LPG; LOG5; 5-LOX |
| NCBI Protein Information: | arachidonate 5-lipoxygenase; LOX-5; leukotriene A4 synthase; arachidonic acid 5-lipoxygenase; arachidonic 5-lipoxygenase alpha-10 isoform; arachidonic 5-lipoxygenase delta-13 isoform; arachidonic 5-lipoxygenase delta-p10 isoform; arachidonic 5-lipoxygenase delta-10-13 isoform |
| UniProt Protein Name: | Arachidonate 5-lipoxygenase |
| Protein Family: | Arachidonate 5-lipoxygenase |
| UniProt Gene Name: | ALOX5 |
| UniProt Entry Name: | LOX5_HUMAN |