Anti-ALDH6A1 Antibody (CAB14750)
- SKU:
- CAB14750
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-ALDH6A1 Antibody |
| 抗体コード: | CAB14750 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | IHC IF |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 326-535 of human ALDH6A1 (NP_005580.1). |
| 申し込み: | IHC IF |
| 推奨希釈: | IHC 1:50 - 1:200 IF 1:50 - 1:200 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 326-535 of human ALDH6A1 (NP_005580.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | VGEA KKWL PELV EHAK NLRV NAGD QPGA DLGP LITP QAKE RVCN LIDS GTKE GASI LLDG RKIK VKGY ENGN FVGP TIIS NVKP NMTC YKEE IFGP VLVV LETE TLDE AIQI VNNN PYGN GTAI FTTN GATA RKYA HLVD VGQV GVNV PIPV PLPM FSFT GSRS SFRG DTNF YGKQ GIQF YTQL KTIT SQWK EEDA TLSS PAVV MPTM GR |
| 遺伝子ID: | 4329 |
| Uniprot: | Q02252 |
| セルラーロケーション: | Mitochondrion |
| 計算された分子量: | 56kDa/57kDa |
| 観察された分子量: |
| 同義語: | ALDH6A1, MMSADHA, MMSDH |
| バックグラウンド: | This gene encodes a member of the aldehyde dehydrogenase protein family. The encoded protein is a mitochondrial methylmalonate semialdehyde dehydrogenase that plays a role in the valine and pyrimidine catabolic pathways. This protein catalyzes the irreversible oxidative decarboxylation of malonate and methylmalonate semialdehydes to acetyl- and propionyl-CoA. Methylmalonate semialdehyde dehydrogenase deficiency is characterized by elevated beta-alanine, 3-hydroxypropionic acid, and both isomers of 3-amino and 3-hydroxyisobutyric acids in urine organic acids. Alternate splicing results in multiple transcript variants. |
| UniProt Protein Function: | ALDH6A1: Plays a role in valine and pyrimidine metabolism. Binds fatty acyl-CoA. Defects in ALDH6A1 are the cause of methylmalonate semialdehyde dehydrogenase deficiency (MMSDHD). This is characterized by elevated beta-alanine, 3-hydroxypropionic acid, and both isomers of 3-amino and 3-hydroxyisobutyric acids in urine organic acids. Belongs to the aldehyde dehydrogenase family. |
| UniProt Protein Details: | Protein type:Carbohydrate Metabolism - inositol phosphate; EC 1.2.1.27; EC 1.2.1.18; Mitochondrial; Oxidoreductase; Carbohydrate Metabolism - propanoate; Amino Acid Metabolism - valine, leucine and isoleucine degradation Chromosomal Location of Human Ortholog: 14q24.3 Cellular Component: nucleoplasm; mitochondrion; mitochondrial matrix Molecular Function:aldehyde dehydrogenase (NAD) activity; acyl-CoA binding; methylmalonate-semialdehyde dehydrogenase (acylating) activity; malonate-semialdehyde dehydrogenase (acetylating) activity Biological Process: valine catabolic process; thymine metabolic process; brown fat cell differentiation; thymine catabolic process; valine metabolic process; branched chain family amino acid catabolic process Disease: Methylmalonate Semialdehyde Dehydrogenase Deficiency |
| NCBI Summary: | This gene encodes a member of the aldehyde dehydrogenase protein family. The encoded protein is a mitochondrial methylmalonate semialdehyde dehydrogenase that plays a role in the valine and pyrimidine catabolic pathways. This protein catalyzes the irreversible oxidative decarboxylation of malonate and methylmalonate semialdehydes to acetyl- and propionyl-CoA. Methylmalonate semialdehyde dehydrogenase deficiency is characterized by elevated beta-alanine, 3-hydroxypropionic acid, and both isomers of 3-amino and 3-hydroxyisobutyric acids in urine organic acids. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013] |
| UniProt Code: | Q02252 |
| NCBI GenInfo Identifier: | 12643424 |
| NCBI Gene ID: | 4329 |
| NCBI Accession: | Q02252.2 |
| UniProt Secondary Accession: | Q02252,Q9UKM8, B2R609, B4DFS8, J3KNU8, |
| UniProt Related Accession: | Q02252 |
| Molecular Weight: | 535 |
| NCBI Full Name: | Methylmalonate-semialdehyde dehydrogenase |
| NCBI Synonym Full Names: | aldehyde dehydrogenase 6 family, member A1 |
| NCBI Official Symbol: | ALDH6A1 |
| NCBI Official Synonym Symbols: | MMSDH; MMSADHA |
| NCBI Protein Information: | methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial; methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial; mitochondrial acylating methylmalonate-semialdehyde dehydrogenase |
| UniProt Protein Name: | Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial |
| UniProt Synonym Protein Names: | Aldehyde dehydrogenase family 6 member A1 |
| UniProt Gene Name: | ALDH6A1 |
| UniProt Entry Name: | MMSA_HUMAN |
 | Immunohistochemistry of paraffin-embedded rat ovary using ALDH6A1 antibody (CAB14750) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human stomach using ALDH6A1 antibody (CAB14750) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded mouse kidney using ALDH6A1 antibody (CAB14750) at dilution of 1:100 (40x lens). |
 | Immunofluorescence analysis of HeLa cells using ALDH6A1 Polyclonal Antibody (CAB14750) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining. |
 | Immunofluorescence analysis of NIH-3T3 cells using ALDH6A1 Polyclonal Antibody (CAB14750) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining. |
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