Anti-AKAP6 Antibody (CAB12798)
- SKU:
- CAB12798
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-AKAP6 Antibody |
| 抗体コード: | CAB12798 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human AKAP6 (NP_004265.3). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:1000 |
| 反応性: | Human |
| ポジティブサンプル: | U-87MG, SH-SY5Y |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human AKAP6 (NP_004265.3). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MLTM SVTL SPLR SQDL DPMA TDAS PMAI NMTP TVEQ GEGE EAMK DMDS DQQY EKPP PLHT GADW KIVL HLPE IETW LRMT SERV RDLT YSVQ QDSD SKHV DVHL VQLK DICE DISD HVEQ IHAL LETE FSLK LLSY SVNV IVDI HAVQ LLWH QLRV SVLV LRER ILQG LQDA NGNY TRQT DILQ AFSE ETKE GRLD SLTE VDDS GQLT IKCS QNYL SLDC GITA FELS DYSP SEDL LSGL GDMT SSQV KTKP FDSW SYSE MEKE FPEL IR |
| 遺伝子ID: | 9472 |
| Uniprot: | Q13023 |
| セルラーロケーション: | Nucleus membrane, Sarcoplasmic reticulum |
| 計算された分子量: | 120kDa/256kDa |
| 観察された分子量: | 105kDa |
| 同義語: | AKAP6, ADAP100, ADAP6, AKAP100, PRKA6, mAKAP |
| バックグラウンド: | The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein is highly expressed in various brain regions and cardiac and skeletal muscle. It is specifically localized to the sarcoplasmic reticulum and nuclear membrane, and is involved in anchoring PKA to the nuclear membrane or sarcoplasmic reticulum. |
| UniProt Protein Function: | AKAP6: Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the nuclear membrane or sarcoplasmic reticulum. May act as an adapter for assembling multiprotein complexes. |
| UniProt Protein Details: | Protein type:Adaptor/scaffold Chromosomal Location of Human Ortholog: 14q12 Cellular Component: caveola; cytoplasm; nuclear envelope; perinuclear region of cytoplasm; sarcoplasmic reticulum; T-tubule Molecular Function:adenylate cyclase binding; protein anchor; protein binding; protein complex scaffold; protein kinase A binding Biological Process: negative regulation of cAMP biosynthetic process; positive regulation of cell growth; positive regulation of NFAT protein import into nucleus; positive regulation of phosphoprotein phosphatase activity; positive regulation of release of sequestered calcium ion into cytosol; regulation of action potential |
| NCBI Summary: | The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein is highly expressed in various brain regions and cardiac and skeletal muscle. It is specifically localized to the sarcoplasmic reticulum and nuclear membrane, and is involved in anchoring PKA to the nuclear membrane or sarcoplasmic reticulum. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q13023 |
| NCBI GenInfo Identifier: | 116241243 |
| NCBI Gene ID: | 9472 |
| NCBI Accession: | Q13023.3 |
| UniProt Secondary Accession: | Q13023,O15028, A7E242, A7E2D4, |
| UniProt Related Accession: | Q13023 |
| Molecular Weight: | 257kDa |
| NCBI Full Name: | A-kinase anchor protein 6 |
| NCBI Synonym Full Names: | A-kinase anchoring protein 6 |
| NCBI Official Symbol: | AKAP6 |
| NCBI Official Synonym Symbols: | ADAP6; PRKA6; mAKAP; ADAP100; AKAP100 |
| NCBI Protein Information: | A-kinase anchor protein 6 |
| UniProt Protein Name: | A-kinase anchor protein 6 |
| UniProt Synonym Protein Names: | A-kinase anchor protein 100 kDa; AKAP 100; Protein kinase A-anchoring protein 6; PRKA6; mAKAP |
| Protein Family: | A-kinase anchor protein |
| UniProt Gene Name: | AKAP6 |
 | Western blot analysis of extracts of various cell lines, using AKAP6 antibody (CAB12798) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90s. |
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