Anti-ADD3 Antibody (CAB18336)
- SKU:
- CAB18336
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
Frequently bought together:
Description
| 抗体名: | Anti-ADD3 Antibody |
| 抗体コード: | CAB18336 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse |
| 宿主種: | Rabbit |
| 免疫原: | A synthetic peptide corresponding to a sequence within amino acids 400-500 of human ADD3 (NP_001307523.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse |
| ポジティブサンプル: |
| 免疫原: | A synthetic peptide corresponding to a sequence within amino acids 400-500 of human ADD3 (NP_001307523.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | Email for sequence |
| 遺伝子ID: | 120 |
| Uniprot: | Q9UEY8 |
| セルラーロケーション: | |
| 計算された分子量: | |
| 観察された分子量: | Refer to figures |
| 同義語: | ADDL, CPSQ3, ADD3 |
| バックグラウンド: |
| UniProt Protein Function: | ADD3: is a heteromeric protein composed of different subunits referred to as adducin alpha, beta and gamma. The three subunits are encoded by distinct genes and belong to a family of membrane skeletal proteins involved in the assembly of spectrin-actin network in erythrocytes and at sites of cell-cell contact in epithelial tissues. Adducins alpha and gamma are ubiquitously expressed, while the expression of adducin beta is restricted to brain and hematopoietic tissues. Adducin, originally purified from human erythrocytes, was found to be a heterodimer of adducins alpha and beta. Polymorphisms resulting in amino acid substitutions of alpha and beta have been associated with the regulation of blood pressure in an animal model of hypertension. Heterodimers consisting of alpha and gamma subunits have been described. Structurally, each subunit is comprised of two distinct domains. The amino-terminal region is protease resistant and globular in shape, while the carboxy-terminal region is protease sensitive. The latter contains multiple phosphorylation sites, the binding site for calmodulin, and is required for association with spectrin and actin. Alternatively spliced adducin gamma transcripts encoding different isoforms have been described. |
| UniProt Protein Details: | Protein type:Cytoskeletal; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 10q25.2 Cellular Component: cytoplasm; cytosol; membrane; nucleoplasm; plasma membrane Molecular Function:structural constituent of cytoskeleton Biological Process: transmembrane transport |
| NCBI Summary: | Adducins are heteromeric proteins composed of different subunits referred to as adducin alpha, beta and gamma. The three subunits are encoded by distinct genes and belong to a family of membrane skeletal proteins involved in the assembly of spectrin-actin network in erythrocytes and at sites of cell-cell contact in epithelial tissues. While adducins alpha and gamma are ubiquitously expressed, the expression of adducin beta is restricted to brain and hematopoietic tissues. Adducin, originally purified from human erythrocytes, was found to be a heterodimer of adducins alpha and beta. Polymorphisms resulting in amino acid substitutions in these two subunits have been associated with the regulation of blood pressure in an animal model of hypertension. Heterodimers consisting of alpha and gamma subunits have also been described. Structurally, each subunit is comprised of two distinct domains. The amino-terminal region is protease resistant and globular in shape, while the carboxy-terminal region is protease sensitive. The latter contains multiple phosphorylation sites for protein kinase C, the binding site for calmodulin, and is required for association with spectrin and actin. Alternatively spliced adducin gamma transcripts encoding different isoforms have been described. The functions of the different isoforms are not known. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9UEY8 |
| NCBI GenInfo Identifier: | 12643881 |
| NCBI Gene ID: | 120 |
| NCBI Accession: | Q9UEY8.1 |
| UniProt Secondary Accession: | Q9UEY8,O43243, Q5VU09, Q92773, Q9UEY7, D3DRA8, |
| UniProt Related Accession: | Q9UEY8 |
| Molecular Weight: | 75,671 Da |
| NCBI Full Name: | Gamma-adducin |
| NCBI Synonym Full Names: | adducin 3 |
| NCBI Official Symbol: | ADD3 |
| NCBI Official Synonym Symbols: | ADDL; CPSQ3 |
| NCBI Protein Information: | gamma-adducin |
| UniProt Protein Name: | Gamma-adducin |
| UniProt Synonym Protein Names: | Adducin-like protein 70 |
| Protein Family: | Gamma-adducin |
| UniProt Gene Name: | ADD3 |
| UniProt Entry Name: | ADDG_HUMAN |