Anti-ACTN2 Antibody (CAB8939)
- SKU:
- CAB8939
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Monoclonal Antibody
- Research Area:
- Cell Biology
Description
| 抗体名: | Anti-ACTN2 Antibody |
| 抗体コード: | CAB8939 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IF |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | A synthesized peptide derived from human ACTN2 |
| 申し込み: | WB IF |
| 推奨希釈: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | RD, Mouse lung, Mouse skeletal muscle, Mouse heart, Rat skeletal muscle |
| 免疫原: | A synthesized peptide derived from human ACTN2 |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | Email for sequence |
| 遺伝子ID: | 88 |
| Uniprot: | P35609 |
| セルラーロケーション: | |
| 計算された分子量: | 103kDa |
| 観察された分子量: | 104KDa |
| 同義語: | CMD1AA, CMH23 |
| バックグラウンド: | Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a muscle-specific, alpha actinin isoform that is expressed in both skeletal and cardiac muscles. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2013] |
| UniProt Protein Function: | ACTN2: F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. Defects in ACTN2 are the cause of cardiomyopathy dilated type 1AA (CMD1AA). Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death. Belongs to the alpha-actinin family. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Cytoskeletal Chromosomal Location of Human Ortholog: 1q42-q43 Cellular Component: cortical actin cytoskeleton; cytoskeleton; focal adhesion; extracellular region; dendritic spine; actin filament; pseudopodium; Z disc; cytosol; filopodium Molecular Function:actin filament binding; protein dimerization activity; integrin binding; identical protein binding; protein binding; LIM domain binding; structural constituent of muscle; cytoskeletal protein binding; titin binding; calcium ion binding; FATZ binding; thyroid hormone receptor coactivator activity Biological Process: focal adhesion formation; platelet activation; negative regulation of potassium ion transport; positive regulation of potassium ion transport; muscle filament sliding; protein homotetramerization; regulation of apoptosis; synaptic transmission; regulation of membrane potential; platelet degranulation; microspike biogenesis; blood coagulation; cell adhesion Disease: Cardiomyopathy, Dilated, 1aa |
| NCBI Summary: | Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a muscle-specific, alpha actinin isoform that is expressed in both skeletal and cardiac muscles. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2013] |
| UniProt Code: | P35609 |
| NCBI GenInfo Identifier: | 543742 |
| NCBI Gene ID: | 88 |
| NCBI Accession: | P35609.1 |
| UniProt Secondary Accession: | P35609,Q86TF4, Q86TI8, B1ANE4, B2RCS5, |
| UniProt Related Accession: | P35609 |
| Molecular Weight: | 103,920 Da |
| NCBI Full Name: | Alpha-actinin-2 |
| NCBI Synonym Full Names: | actinin, alpha 2 |
| NCBI Official Symbol: | ACTN2 |
| NCBI Official Synonym Symbols: | CMD1AA |
| NCBI Protein Information: | alpha-actinin-2; F-actin cross-linking protein; alpha-actinin skeletal muscle |
| UniProt Protein Name: | Alpha-actinin-2 |
| UniProt Synonym Protein Names: | Alpha-actinin skeletal muscle isoform 2; F-actin cross-linking protein |
| Protein Family: | Alpha-actinin |
| UniProt Gene Name: | ACTN2 |
| UniProt Entry Name: | ACTN2_HUMAN |
 | Western blot - ACTN2 Rabbit mAb (CAB8939) |