Anti-ACO2 Antibody (RACO0514)
- SKU:
- RACO0514
- Product type:
- Recombinant Antibody
- Reactivity:
- Human
- Host Species:
- Human
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Conjugation:
- Unconjugated
Frequently bought together:
Description
| 商品名: | ACO2 Antibody |
| Product SKU: | RACO0514 |
| サイズ: | 50ul |
| 宿主種: | Homo sapiens (Human) |
| 申し込み: | ELISA, IHC |
| 推奨される希釈: | IHC:1:50-1:200 |
| 反応性: | Human |
| 免疫原: | A synthesized peptide derived from human Aconitase 2 |
| 憲法: | Liquid |
| ストレージバッファ: | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| 精製方法: | Affinity-chromatography |
| 抗体のクローン性: | Monoclonal |
| アイソタイプ: | Rabbit IgG |
| Conjugate: | Non-conjugated |
| バックグラウンド: | Catalyzes the isomerization of citrate to isocitrate via cis-aconitate. |
| シノニム: | Aconitate hydratase, mitochondrial (Aconitase) (EC 4.2.1.3) (Citrate hydro-lyase), ACO2 |
 | IHC image of RACO0514 diluted at 1:100 and staining in paraffin-embedded human kidney tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB. |
 | IHC image of RACO0514 diluted at 1:100 and staining in paraffin-embedded human lung cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB. |
| UniProt Protein Function: | ACO2: Catalyzes the isomerization of citrate to isocitrate via cis-aconitate. Monomer. Belongs to the aconitase/IPM isomerase family. |
| UniProt Protein Details: | Protein type:Lyase; EC 4.2.1.3; Carbohydrate Metabolism - glyoxylate and dicarboxylate; Carbohydrate Metabolism - citrate (TCA) cycle; Mitochondrial Chromosomal Location of Human Ortholog: 22q13.2 Cellular Component: mitochondrion; mitochondrial matrix; nucleus Molecular Function:iron ion binding; 4 iron, 4 sulfur cluster binding; aconitate hydratase activity; 3 iron, 4 sulfur cluster binding Biological Process: isocitrate metabolic process; cellular metabolic process; generation of precursor metabolites and energy; tricarboxylic acid cycle; citrate metabolic process Disease: Infantile Cerebellar-retinal Degeneration; Optic Atrophy 8 |
| NCBI Summary: | The protein encoded by this gene belongs to the aconitase/IPM isomerase family. It is an enzyme that catalyzes the interconversion of citrate to isocitrate via cis-aconitate in the second step of the TCA cycle. This protein is encoded in the nucleus and functions in the mitochondrion. It was found to be one of the mitochondrial matrix proteins that are preferentially degraded by the serine protease 15(PRSS15), also known as Lon protease, after oxidative modification. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q99798 |
| NCBI GenInfo Identifier: | 6686275 |
| NCBI Gene ID: | 50 |
| NCBI Accession: | Q99798.2 |
| UniProt Related Accession: | Q99798 |
| Molecular Weight: | |
| NCBI Full Name: | Aconitate hydratase, mitochondrial |
| NCBI Synonym Full Names: | aconitase 2 |
| NCBI Official Symbol: | ACO2 |
| NCBI Official Synonym Symbols: | ICRD; OCA8; OPA9; ACONM; HEL-S-284 |
| NCBI Protein Information: | aconitate hydratase, mitochondrial |
| UniProt Protein Name: | Aconitate hydratase, mitochondrial |
| UniProt Synonym Protein Names: | Citrate hydro-lyase |
| Protein Family: | Aconitate hydratase |
| UniProt Gene Name: | ACO2 |
| UniProt Entry Name: | ACON_HUMAN |