Anti-AADAC Antibody (CAB10365)
- SKU:
- CAB10365
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-AADAC Antibody |
| 抗体コード: | CAB10365 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IHC |
| 反応性: | Human, Mouse |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 170-399 of human AADAC (NP_001077.2). |
| 申し込み: | WB IHC |
| 推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:100 |
| 反応性: | Human, Mouse |
| ポジティブサンプル: | A-549, Mouse liver |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 170-399 of human AADAC (NP_001077.2). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | KKVL AKYG VNPE RIGI SGDS AGGN LAAA VTQQ LLDD PDVK IKLK IQSL IYPA LQPL DVDL PSYQ ENSN FLFL SKSL MVRF WSEY FTTD RSLE KAML SRQH VPVE SSHL FKFV NWSS LLPE RFIK GHVY NNPN YGSS ELAK KYPG FLDV RAAP LLAD DNKL RGLP LTYV ITCQ YDLL RDDG LMYV TRLR NTGV QVTH NHVE DGFH GAFS FLGL KISH RLIN QYIE WLKE NL |
| 遺伝子ID: | 13 |
| Uniprot: | P22760 |
| セルラーロケーション: | Endoplasmic reticulum membrane, Microsome membrane, Single-pass type II membrane protein |
| 計算された分子量: | 45kDa |
| 観察された分子量: | 46kDa |
| 同義語: | AADAC, CES5A1, DAC |
| バックグラウンド: | Microsomal arylacetamide deacetylase competes against the activity of cytosolic arylamine N-acetyltransferase, which catalyzes one of the initial biotransformation pathways for arylamine and heterocyclic amine carcinogens |
| UniProt Protein Function: | AADAC: Arylacetamide deacetylation is an important enzyme activity in the metabolic activation of arylamine substrates to ultimate carcinogens. Displays major serine hydrolase activity in liver microsomes. Hydrolyzes also flutamide, which is an antiandrogen drug used for the treatment of prostate cancer that occasionaly causes severe hepatotoxicity. Displays cellular triglyceride lipase activity in liver. Increases intracellular fatty acids derived from hydrolysis of newly formed triglyceride stores. Belongs to the 'GDXG' lipolytic enzyme family. |
| UniProt Protein Details: | Protein type:Deacetylase; Endoplasmic reticulum; Motility/polarity/chemotaxis; Lipase; Membrane protein, integral; EC 3.1.1.3 Chromosomal Location of Human Ortholog: 3q25.1 Cellular Component: endoplasmic reticulum membrane Molecular Function:catalytic activity; deacetylase activity; lipase activity; serine hydrolase activity; triacylglycerol lipase activity Biological Process: xenobiotic metabolic process |
| NCBI Summary: | Microsomal arylacetamide deacetylase competes against the activity of cytosolic arylamine N-acetyltransferase, which catalyzes one of the initial biotransformation pathways for arylamine and heterocyclic amine carcinogens [provided by RefSeq, Jul 2008] |
| UniProt Code: | P22760 |
| NCBI GenInfo Identifier: | 317373587 |
| NCBI Gene ID: | 13 |
| NCBI Accession: | P22760.5 |
| UniProt Secondary Accession: | P22760,Q8N1A9, A8K3L3, D3DNJ6, |
| UniProt Related Accession: | P22760 |
| Molecular Weight: | 45,734 Da |
| NCBI Full Name: | Arylacetamide deacetylase |
| NCBI Synonym Full Names: | arylacetamide deacetylase |
| NCBI Official Symbol: | AADAC |
| NCBI Official Synonym Symbols: | DAC; CES5A1 |
| NCBI Protein Information: | arylacetamide deacetylase |
| UniProt Protein Name: | Arylacetamide deacetylase |
| Protein Family: | Arylacetamide deacetylase |
| UniProt Gene Name: | AADAC |
| UniProt Entry Name: | AAAD_HUMAN |
 | Western blot analysis of extracts of various cell lines, using AADAC antibody (CAB10365) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
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