ZNRF3 Antibody, Biotin conjugated (PACO42365)
- SKU:
- PACO42365
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- Biotin
Frequently bought together:
Description
抗体名: | ZNRF3 Antibody, Biotin conjugated (PACO42365) |
抗体コード: | PACO42365 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human E3 ubiquitin-protein ligase ZNRF3 protein (56-219AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Biotin |
バックグラウンド: | E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination and subsequent degradation of Wnt receptor complex components Frizzled and LRP6. Acts on both canonical and non-canonical Wnt signaling pathway. Acts as a tumor suppressor in the intestinal stem cell zone by inhibiting the Wnt signaling pathway, thereby resticting the size of the intestinal stem cell zone. |
シノニム: | E3 ubiquitin-protein ligase ZNRF3 (EC 2.3.2.27) (RING finger protein 203) (RING-type E3 ubiquitin transferase ZNRF3) (Zinc/RING finger protein 3), ZNRF3, KIAA1133 RNF203 |
UniProt Protein Function: | ZNRF3: E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination and subsequent degradation of Wnt receptor complex components Frizzled and LRP6. Acts on both canonical and non- canonical Wnt signaling pathway. Acts as a tumor suppressor in the intestinal stem cell zone by inhibiting the Wnt signaling pathway, thereby resticting the size of the intestinal stem cell zone. Belongs to the ZNRF3 family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:EC 6.3.2.19; Ubiquitin conjugating system; Membrane protein, integral; Ubiquitin ligase; EC 6.3.2.- Chromosomal Location of Human Ortholog: 22q12.1 Cellular Component: integral to plasma membrane; plasma membrane Molecular Function:frizzled binding; ligase activity; protein binding; ubiquitin-protein ligase activity; zinc ion binding Biological Process: protein ubiquitination; ubiquitin-dependent protein catabolic process; Wnt receptor signaling pathway through beta-catenin; Wnt receptor signaling pathway, planar cell polarity pathway |
UniProt Code: | Q9ULT6 |
NCBI GenInfo Identifier: | 332801080 |
NCBI Gene ID: | 84133 |
NCBI Accession: | NP_001193927.1 |
UniProt Secondary Accession: | Q9ULT6,Q6ICH1, Q6NTF8, Q8WU18, B3KU18, |
UniProt Related Accession: | Q9ULT6 |
Molecular Weight: | 34.2 kDa |
NCBI Full Name: | E3 ubiquitin-protein ligase ZNRF3 isoform 1 |
NCBI Synonym Full Names: | zinc and ring finger 3 |
NCBI Official Symbol: | ZNRF3 |
NCBI Official Synonym Symbols: | RNF203; BK747E2.3 |
NCBI Protein Information: | E3 ubiquitin-protein ligase ZNRF3 |
UniProt Protein Name: | E3 ubiquitin-protein ligase ZNRF3 |
UniProt Synonym Protein Names: | RING finger protein 203; Zinc/RING finger protein 3 |
Protein Family: | E3 ubiquitin-protein ligase |
UniProt Gene Name: | ZNRF3 |
UniProt Entry Name: | ZNRF3_HUMAN |