UniProt Protein Function: | ZNRD1: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I which synthesizes ribosomal RNA precursors. Belongs to the archaeal RpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. |
UniProt Protein Details: | Protein type:Transcription initiation complex; Transferase; Nucleolus Chromosomal Location of Human Ortholog: 6p21.3 Cellular Component: DNA-directed RNA polymerase I complex; nucleoplasm Biological Process: nucleobase, nucleoside, nucleotide and nucleic acid metabolic process; positive regulation of gene expression, epigenetic; RNA elongation from RNA polymerase I promoter; termination of RNA polymerase I transcription; transcription initiation from RNA polymerase I promoter |
NCBI Summary: | This gene encodes a DNA-directed RNA polymerase I subunit. The encoded protein contains two potential zinc-binding motifs and may play a role in regulation of cell proliferation. The encoded protein may be involved in cancer and human immunodeficiency virus progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013] |
UniProt Code: | Q9P1U0 |
NCBI GenInfo Identifier: | 71649339 |
NCBI Gene ID: | 30834 |
NCBI Accession: | Q9P1U0.1 |
UniProt Secondary Accession: | Q9P1U0,Q1RMP0, Q5TM50, Q791N7, Q1XHV8, Q6MFY5, |
UniProt Related Accession: | Q9P1U0 |
Molecular Weight: | 13,904 Da |
NCBI Full Name: | DNA-directed RNA polymerase I subunit RPA12 |
NCBI Synonym Full Names: | zinc ribbon domain containing 1 |
NCBI Official Symbol: | ZNRD1 |
NCBI Official Synonym Symbols: | TEX6; ZR14; HTEX6; Rpa12; hZR14; HTEX-6; TCTEX6; tctex-6 |
NCBI Protein Information: | DNA-directed RNA polymerase I subunit RPA12 |
UniProt Protein Name: | DNA-directed RNA polymerase I subunit RPA12 |
UniProt Synonym Protein Names: | Zinc ribbon domain-containing protein 1 |
UniProt Gene Name: | ZNRD1 |
UniProt Entry Name: | RPA12_HUMAN |