UniProt Protein Function: | Early endosomal protein that functions to recruit SMAD2/SMAD3 to intracellular membranes and to the TGF-beta receptor. Plays a significant role in TGF-mediated signaling by regulating the subcellular location of SMAD2 and SMAD3 and modulating the transcriptional activity of the SMAD3/SMAD4 complex. Possibly associated with TGF-beta receptor internalization. |
NCBI Summary: | This gene encodes a double zinc finger motif-containing protein that participates in the transforming growth factor-beta (TGFB) signalling pathway. The encoded protein interacts directly with SMAD2 and SMAD3, and recruits SMAD2 to the TGFB receptor. There are multiple pseudogenes for this gene on chromosomes 2, 15, and X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013] |
UniProt Code: | O95405 |
NCBI GenInfo Identifier: | 47717106 |
NCBI Gene ID: | 9372 |
NCBI Accession: | NP_004790.2 |
UniProt Secondary Accession: | O95405,Q5T0F6, Q5T0F7, Q9UNE1, Q9Y5R7, |
UniProt Related Accession: | O95405 |
Molecular Weight: | 83,721 Da |
NCBI Full Name: | zinc finger FYVE domain-containing protein 9 isoform 3 |
NCBI Synonym Full Names: | zinc finger FYVE-type containing 9 |
NCBI Official Symbol: | ZFYVE9 |
NCBI Official Synonym Symbols: | NSP; SARA; MADHIP; SMADIP; PPP1R173 |
NCBI Protein Information: | zinc finger FYVE domain-containing protein 9 |
UniProt Protein Name: | Zinc finger FYVE domain-containing protein 9 |
UniProt Synonym Protein Names: | Mothers against decapentaplegic homolog-interacting protein; Madh-interacting protein; Novel serine protease; NSP; Receptor activation anchor; hSARA; Smad anchor for receptor activation |
Protein Family: | Sarafotoxin |
UniProt Gene Name: | ZFYVE9 |