UniProt Protein Function: | endofin: May be involved in regulating membrane trafficking in the endosomal pathway. Overexpression induces endosome aggregation. Required to target TOM1 to endosomes. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Lipid-binding Chromosomal Location of Human Ortholog: 5q14 Cellular Component: cytoplasm; early endosome; early endosome membrane; intracellular membrane-bound organelle Molecular Function:phosphatidylinositol binding; phosphatidylinositol-3,4,5-triphosphate binding; protein binding; protein transporter activity Biological Process: BMP signaling pathway; endosome transport; protein targeting to lysosome; regulation of endocytosis |
NCBI Summary: | This gene encodes an endosomal protein that belongs to the FYVE zinc finger family of proteins. The encoded protein is thought to regulate membrane trafficking in the endosome. This protein functions as a scaffold protein in the transforming growth factor-beta signaling pathway and is involved in positive and negative feedback regulation of the bone morphogenetic protein signaling pathway. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013] |
UniProt Code: | Q7Z3T8 |
NCBI GenInfo Identifier: | 296453075 |
NCBI Gene ID: | 9765 |
NCBI Accession: | Q7Z3T8.3 |
UniProt Secondary Accession: | Q7Z3T8,O15023, Q5H9U2, Q7LAU7, Q86T69, Q8N5L3, Q8NEK3 |
UniProt Related Accession: | Q7Z3T8 |
Molecular Weight: | 88,377 Da |
NCBI Full Name: | Zinc finger FYVE domain-containing protein 16 |
NCBI Synonym Full Names: | zinc finger FYVE-type containing 16 |
NCBI Official Symbol: | ZFYVE16 |
NCBI Official Synonym Symbols: | PPP1R69 |
NCBI Protein Information: | zinc finger FYVE domain-containing protein 16 |
UniProt Protein Name: | Zinc finger FYVE domain-containing protein 16 |
UniProt Synonym Protein Names: | Endofin; Endosome-associated FYVE domain protein |
Protein Family: | Zinc finger FYVE domain-containing protein |
UniProt Gene Name: | ZFYVE16 |
UniProt Entry Name: | ZFY16_HUMAN |