ZBTB18 Antibody, HRP conjugated (PACO31233)
- SKU:
- PACO31233
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- HRP
Frequently bought together:
Description
抗体名: | ZBTB18 Antibody, HRP conjugated (PACO31233) |
抗体コード: | PACO31233 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Zinc finger and BTB domain-containing protein 18 protein (62-364AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | HRP |
バックグラウンド: | Transcriptional repressor that plays a role in various developmental processes such as myogenesis and brain development. Plays a key role in myogenesis by directly repressing the expression of ID2 and ID3, 2 inhibitors of skeletal myogenesis. Also involved in controlling cell division of progenitor cells and regulating the survival of postmitotic cortical neurons. Specifically binds the consensus DNA sequence 5'-[AC]ACATCTG[GT][AC]-3' which contains the E box core, and acts by recruiting chromatin remodeling multiprotein complexes. May also play a role in the organization of chromosomes in the nucleus. |
シノニム: | Zinc finger and BTB domain-containing protein 18 (58 kDa repressor protein) (Transcriptional repressor RP58) (Translin-associated zinc finger protein 1) (TAZ-1) (Zinc finger protein 238) (Zinc finger protein C2H2-171), ZBTB18, RP58 TAZ1 ZNF238 |
UniProt Protein Function: | ZNF238: Transcriptional repressor that plays a role in various developmental processes such as myogenesis and brain development. Plays a key role in myogenesis by directly repressing the expression of ID2 and ID3, 2 inhibitors of skeletal myogenesis. Also involved in controlling cell division of progenitor cells and regulating the survival of postmitotic cortical neurons. Specifically binds the consensus DNA sequence 5'- [AC]ACATCTG[GT][AC]-3' which contains the E box core, and acts by recruiting chromatin remodeling multiprotein complexes. May also play a role in the organization of chromosomes in the nucleus. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:C2H2-type zinc finger protein; Transcription factor Chromosomal Location of Human Ortholog: 1q44 Cellular Component: intercellular bridge; microtubule cytoskeleton; nuclear chromosome; nucleoplasm; nucleus Molecular Function:DNA binding; protein binding; sequence-specific DNA binding; transcription factor activity Biological Process: negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; skeletal muscle development Disease: Mental Retardation, Autosomal Dominant 22 |
NCBI Summary: | This gene encodes a C2H2-type zinc finger protein which acts a transcriptional repressor of genes involved in neuronal development. The encoded protein recognizes a specific sequence motif and recruits components of chromatin to target genes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013] |
UniProt Code: | Q99592 |
NCBI GenInfo Identifier: | 20141020 |
NCBI Gene ID: | 10472 |
NCBI Accession: | Q99592.1 |
UniProt Secondary Accession: | Q99592,Q13397, Q5VU40, Q8N463, Q9UD99, A8K5U3, |
UniProt Related Accession: | Q99592 |
Molecular Weight: | 59,366 Da |
NCBI Full Name: | Zinc finger and BTB domain-containing protein 18 |
NCBI Synonym Full Names: | zinc finger and BTB domain containing 18 |
NCBI Official Symbol: | ZBTB18 |
NCBI Official Synonym Symbols: | RP58; MRD22; TAZ-1; ZNF238; C2H2-171 |
NCBI Protein Information: | zinc finger and BTB domain-containing protein 18 |
UniProt Protein Name: | Zinc finger and BTB domain-containing protein 18 |
UniProt Synonym Protein Names: | 58 kDa repressor protein; Transcriptional repressor RP58; Translin-associated zinc finger protein 1; TAZ-1; Zinc finger protein 238; Zinc finger protein C2H2-171 |
Protein Family: | Zinc finger and BTB domain-containing protein |
UniProt Gene Name: | ZBTB18 |
UniProt Entry Name: | ZBT18_HUMAN |