ZBP1 Antibody (PACO13289)
- SKU:
- PACO13289
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | ZBP1 Antibody (PACO13289) |
抗体コード: | PACO13289 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IHC |
推奨される希釈: | |
反応性: | Human |
免疫原: | Human ZBP1 |
憲法: | Liquid |
ストレージバッファ: | PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles. |
精製方法: | Antigen Affinity Purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
シノニム: | Z-DNA binding protein 1;ZBP1;C20orf183;DAI;DLM-1;DLM1 ; |
UniProt Protein Function: | ZBP1: Participates in the detection by the host's innate immune system of DNA from viral, bacterial or even host origin. Plays a role in host defense against tumors and pathogens. Acts as a cytoplasmic DNA sensor which, when activated, induces the recruitment of TBK1 and IRF3 to its C-terminal region and activates the downstream interferon regulatory factor (IRF) and NF-kappa B transcription factors, leading to type-I interferon production. ZBP1-induced NF-kappaB activation probably involves the recruitment of the RHIM containing kinases RIPK1 and RIPK3. 5 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; DNA-binding Chromosomal Location of Human Ortholog: 20q13.31 Cellular Component: cytoplasm; nucleus; cytosol Molecular Function:double-stranded RNA adenosine deaminase activity; protein binding; DNA binding; left-handed Z-DNA binding; RNA binding Biological Process: metabolic process; positive regulation of interferon type I production; innate immune response |
NCBI Summary: | This gene encodes a Z-DNA binding protein. The encoded protein plays a role in the innate immune response by binding to foreign DNA and inducing type-I interferon production. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011] |
UniProt Code: | Q9H171 |
NCBI GenInfo Identifier: | 71153189 |
NCBI Gene ID: | 81030 |
NCBI Accession: | Q9H171.2 |
UniProt Secondary Accession: | Q9H171,Q5JY39, Q9BYW4, A2A2F7, B3KVA1, F5GYT1, |
UniProt Related Accession: | Q9H171 |
Molecular Weight: | 429 |
NCBI Full Name: | Z-DNA-binding protein 1 |
NCBI Synonym Full Names: | Z-DNA binding protein 1 |
NCBI Official Symbol: | ZBP1 |
NCBI Official Synonym Symbols: | DAI; DLM1; DLM-1; C20orf183 |
NCBI Protein Information: | Z-DNA-binding protein 1; DNA-dependent activator of IRFs; DNA-dependent activator of IFN-regulatory factors; tumor stroma and activated macrophage protein DLM-1; DNA-dependent activator of interferon regulatory factors |
UniProt Protein Name: | Z-DNA-binding protein 1 |
UniProt Synonym Protein Names: | Tumor stroma and activated macrophage protein DLM-1 |
Protein Family: | Z-DNA-binding protein |
UniProt Gene Name: | ZBP1 |
UniProt Entry Name: | ZBP1_HUMAN |