XRCC3 Antibody (PACO05312)
- SKU:
- PACO05312
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | XRCC3 Antibody (PACO05312) |
抗体コード: | PACO05312 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA, IHC, IF |
推奨される希釈: | ELISA:1:20000, IHC:1:100-1:300, IF:1:200-1:1000 |
反応性: | Human |
免疫原: | Synthesized peptide derived from the Internal region of human XRCC3. |
憲法: | Liquid |
ストレージバッファ: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
精製方法: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
シノニム: | XRCC3; DNA repair protein XRCC3; X-ray repair cross-complementing protein 3 |
UniProt Protein Function: | XRCC3: Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51 and RAD51C. Defects in XRCC3 are the cause of susceptibility to breast cancer (BC). BC is a common malignancy originating from breast epithelial tissue. Breast neoplasms can be distinguished by their histologic pattern. Invasive ductal carcinoma is by far the most common type. Breast cancer is etiologically and genetically heterogeneous. Important genetic factors have been indicated by familial occurrence and bilateral involvement. Mutations at more than one locus can be involved in different families or even in the same case. Defects in XRCC3 are the cause of susceptibility to cutaneous malignant melanoma type 6 (CMM6). CMM6 is a malignant neoplasm of melanocytes, arising de novo or from a pre- existing benign nevus, which occurs most often in the skin but also may involve other sites. Belongs to the RecA family. RAD51 subfamily. |
UniProt Protein Details: | Protein type:DNA repair, damage Chromosomal Location of Human Ortholog: 14q32.3 Cellular Component: mitochondrion; perinuclear region of cytoplasm; cytoplasm; replication fork; nucleus Molecular Function:DNA-dependent ATPase activity; protein binding; four-way junction DNA binding; crossover junction endodeoxyribonuclease activity; ATP binding Biological Process: response to organic substance; DNA repair; DNA catabolic process, endonucleolytic; response to DNA damage stimulus; double-strand break repair via homologous recombination; DNA recombination Disease: Melanoma, Cutaneous Malignant, Susceptibility To, 6; Breast Cancer |
NCBI Summary: | This gene encodes a member of the RecA/Rad51-related protein family that participates in homologous recombination to maintain chromosome stability and repair DNA damage. This gene functionally complements Chinese hamster irs1SF, a repair-deficient mutant that exhibits hypersensitivity to a number of different DNA-damaging agents and is chromosomally unstable. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008] |
UniProt Code: | O43542 |
NCBI GenInfo Identifier: | 20140428 |
NCBI Gene ID: | 7517 |
NCBI Accession: | O43542.1 |
UniProt Secondary Accession: | O43542,O43568, Q9BU18, |
UniProt Related Accession: | O43542 |
Molecular Weight: | 37,850 Da |
NCBI Full Name: | DNA repair protein XRCC3 |
NCBI Synonym Full Names: | X-ray repair complementing defective repair in Chinese hamster cells 3 |
NCBI Official Symbol: | XRCC3 |
NCBI Official Synonym Symbols: | CMM6 |
NCBI Protein Information: | DNA repair protein XRCC3; X-ray repair cross-complementing protein 3 |
UniProt Protein Name: | DNA repair protein XRCC3 |
UniProt Synonym Protein Names: | X-ray repair cross-complementing protein 3 |
Protein Family: | DNA repair protein |
UniProt Gene Name: | XRCC3 |
UniProt Entry Name: | XRCC3_HUMAN |