WNK3 Antibody, HRP conjugated (PACO59370)
- SKU:
- PACO59370
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- HRP
Frequently bought together:
Description
抗体名: | WNK3 Antibody, HRP conjugated (PACO59370) |
抗体コード: | PACO59370 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Serine/threonine-protein kinase WNK3 protein (1018-1181AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | HRP |
バックグラウンド: | Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Phosphorylates WNK4. Regulates the phosphorylation of SLC12A1 and SLC12A2. Increases Ca(2+) influx mediated by TRPV5 and TRPV6 by enhancing their membrane expression level via a kinase-dependent pathway. Inhibits the activity of KCNJ1 by decreasing its expression at the cell membrane in a non-catalytic manner. |
シノニム: | Serine/threonine-protein kinase WNK3 (EC 2.7.11.1) (Protein kinase lysine-deficient 3) (Protein kinase with no lysine 3), WNK3, KIAA1566 PRKWNK3 |
UniProt Protein Function: | WNK3: Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Phosphorylates WNK4. Regulates the phosphorylation of SLC12A1 and SLC12A2. Increases Ca(2+) influx mediated by TRPV5 and TRPV6 by enhancing their membrane expression level via a kinase-dependent pathway. Inhibits the activity of KCNJ1 by decreasing its expression at the cell membrane in a non-catalytic manner. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WNK subfamily. 4 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Protein kinase, Other; EC 2.7.11.1; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Other group; Wnk family Chromosomal Location of Human Ortholog: Xp11.22 Cellular Component: adherens junction; cytoplasm; cytosol; tight junction Molecular Function:ATP binding; chloride channel inhibitor activity; protein binding; protein kinase activity; protein serine/threonine kinase activity Biological Process: negative regulation of apoptosis; positive regulation of calcium ion transport; positive regulation of ion transmembrane transporter activity; protein amino acid autophosphorylation; protein amino acid phosphorylation |
NCBI Summary: | This gene encodes a protein belonging to the 'with no lysine' family of serine-threonine protein kinases. These family members lack the catalytic lysine in subdomain II, and instead have a conserved lysine in subdomain I. This family member functions as a positive regulator of the transcellular Ca2+ transport pathway, and it plays a role in the increase of cell survival in a caspase-3-dependent pathway. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010] |
UniProt Code: | Q9BYP7 |
NCBI GenInfo Identifier: | 353526307 |
NCBI Gene ID: | 65267 |
NCBI Accession: | Q9BYP7.3 |
UniProt Secondary Accession: | Q9BYP7,Q5JRC1, Q6JP76, Q8TCX6, Q9HCK6, B1AKG2, |
UniProt Related Accession: | Q9BYP7 |
Molecular Weight: | 192,875 Da |
NCBI Full Name: | Serine/threonine-protein kinase WNK3 |
NCBI Synonym Full Names: | WNK lysine deficient protein kinase 3 |
NCBI Official Symbol: | WNK3 |
NCBI Official Synonym Symbols: | PRKWNK3 |
NCBI Protein Information: | serine/threonine-protein kinase WNK3 |
UniProt Protein Name: | Serine/threonine-protein kinase WNK3 |
UniProt Synonym Protein Names: | Protein kinase lysine-deficient 3; Protein kinase with no lysine 3 |
Protein Family: | Serine/threonine-protein kinase |
UniProt Gene Name: | WNK3 |
UniProt Entry Name: | WNK3_HUMAN |