WISP3 Antibody (PACO52050)
- SKU:
- PACO52050
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | WISP3 Antibody (PACO52050) |
抗体コード: | PACO52050 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IHC |
推奨される希釈: | ELISA:1:2000-1:10000, WB:1:500-1:5000, IHC:1:20-1:200 |
反応性: | Human, Mouse, Rat |
免疫原: | Recombinant Human WNT1-inducible-signaling pathway protein 3 protein (201-372AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
![]() | Western Blot. Positive WB detected in: HepG2 whole cell lysate, Rat heart tissue, Mouse heart tissue. All lanes: WISP3 antibody at 3.5µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 40, 42 kDa. Observed band size: 40 kDa. |
![]() | Immunohistochemistry of paraffin-embedded human liver cancer using PACO52050 at dilution of 1:100. |
![]() | Immunohistochemistry of paraffin-embedded human kidney tissue using PACO52050 at dilution of 1:100. |
バックグラウンド: | Appears to be required for normal postnatal skeletal growth and cartilage homeostasis. |
シノニム: | WNT1-inducible-signaling pathway protein 3 (WISP-3) (CCN family member 6), WISP3, CCN6 |
UniProt Protein Function: | WISP3: Appears to be required for normal postnatal skeletal growth and cartilage homeostasis. Defects in WISP3 are the cause of progressive pseudorheumatoid arthropathy of childhood (PPAC). PPAC is an autosomal recessive disorder characterized by stiffness and swelling of joints, motor weakness and joint contractures. Signs and symptoms of the disease develop typically between three and eight years of age. This progressive disease is a primary disorder of articular cartilage with continued cartilage loss and destructive bone changes with aging. Belongs to the CCN family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Secreted; Cell cycle regulation; Secreted, signal peptide Chromosomal Location of Human Ortholog: 6q21 Cellular Component: proteinaceous extracellular matrix Molecular Function:heparin binding; integrin binding Biological Process: cell adhesion; cell-cell signaling; signal transduction Disease: Arthropathy, Progressive Pseudorheumatoid, Of Childhood |
NCBI Summary: | This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like domain. This gene is overexpressed in colon tumors. It may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. Mutations of this gene are associated with progressive pseudorheumatoid dysplasia, an autosomal recessive skeletal disorder, indicating that the gene is essential for normal postnatal skeletal growth and cartilage homeostasis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
UniProt Code: | O95389 |
NCBI GenInfo Identifier: | 34098394 |
NCBI Gene ID: | 8838 |
NCBI Accession: | O95389.1 |
UniProt Secondary Accession: | O95389,Q3KR29, Q5H8W4, Q6UXH6, |
UniProt Related Accession: | O95389 |
Molecular Weight: | 41,402 Da |
NCBI Full Name: | WNT1-inducible-signaling pathway protein 3 |
NCBI Synonym Full Names: | WNT1 inducible signaling pathway protein 3 |
NCBI Official Symbol: | WISP3 |
NCBI Official Synonym Symbols: | PPD; CCN6; LIBC; PPAC; WISP-3 |
NCBI Protein Information: | WNT1-inducible-signaling pathway protein 3 |
UniProt Protein Name: | WNT1-inducible-signaling pathway protein 3 |
UniProt Synonym Protein Names: | CCN family member 6 |
Protein Family: | WNT1-inducible-signaling pathway protein |
UniProt Gene Name: | WISP3 |
UniProt Entry Name: | WISP3_HUMAN |
Antibodies | ELISA Kits |
Anti-WISP3 Antibody (CAB14812) | Human WISP3 / CCN6 ELISA Kit |
WISP3 Antibody (PACO07312) | Human WNT1-inducible-signaling pathway protein 3 (WISP3) ELISA Kit |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |