WDFY2 Antibody, Biotin conjugated (PACO59324)
- SKU:
- PACO59324
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- Biotin
Frequently bought together:
Description
抗体名: | WDFY2 Antibody, Biotin conjugated (PACO59324) |
抗体コード: | PACO59324 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human WD repeat and FYVE domain-containing protein 2 protein (2-114AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Biotin |
バックグラウンド: | Acts in an adapter protein-like fashion to mediate the interaction between the kinase PRKCZ and its substrate VAMP2 and increases the PRKCZ-dependent phosphorylation of VAMP2. Positively regulates adipocyte differentiation, by facilitating the phosphorylation and thus inactivation of the anti-adipogenetic transcription factor FOXO1 by the kinase AKT1. Plays a role in endosomal control of AKT2 signaling; required for insulin-stimulated AKT2 phosphorylation and glucose uptake and insulin-stimulated phosphorylation of AKT2 substrates (By similarity). Participates in transferrin receptor endocytosis. |
シノニム: | WD repeat and FYVE domain-containing protein 2 (Propeller-FYVE protein) (Prof) (WD40- and FYVE domain-containing protein 2) (Zinc finger FYVE domain-containing protein 22), WDFY2, WDF2 ZFYVE22 |
UniProt Protein Function: | WDFY2: Acts in an adapter protein-like fashion to mediate the interaction between the kinase PRKCZ and its substrate VAMP2 and increases the PRKCZ-dependent phosphorylation of VAMP2 (PubMed:17313651). Positively regulates adipocyte differentiation, by facilitating the phosphorylation and thus inactivation of the anti-adipogenetic transcription factor FOXO1 by the kinase AKT1 (PubMed:18388859). Plays a role in endosomal control of AKT2 signaling; required for insulin-stimulated AKT2 phosphorylation and glucose uptake and insulin-stimulated phosphorylation of AKT2 substrates. Participates in transferrin receptor endocytosis (PubMed:16873553). {ECO:0000250|UniProtKB:Q8BUB4, ECO:0000269|PubMed:16873553, ECO:0000269|PubMed:17313651, ECO:0000269|PubMed:18388859}. Homodimer (PubMed:16792529). Interacts (via WD repeats 1- 3) with AKT1, AKT2, PRKCZ and PRKCI (PubMed:16792529). Interacts with VAMP2 (PubMed:17313651). Forms a complex with VAMP2 and PRKCZ (PubMed:17313651). Interacts with FOXO1. Forms a complex with AKT1 and FOXO1. {ECO:0000250|UniProtKB:Q8BUB4, ECO:0000269|PubMed:16792529, ECO:0000269|PubMed:17313651} |
UniProt Protein Details: | Chromosomal Location of Human Ortholog: 13q14.3 Cellular Component: early endosome; vesicle Molecular Function:protein binding Biological Process: positive regulation of fat cell differentiation; positive regulation of protein amino acid phosphorylation |
NCBI Summary: | This gene encodes a protein that contains two WD domains and an FYVE zinc finger region. The function of this gene is unknown. An alternatively spliced transcript variant of this gene may exist. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q96P53 |
NCBI GenInfo Identifier: | 51316902 |
NCBI Gene ID: | 115825 |
NCBI Accession: | Q96P53.2 |
UniProt Secondary Accession: | Q96P53,Q96CS1, B1AL86, |
UniProt Related Accession: | Q96P53 |
Molecular Weight: | 45kDa |
NCBI Full Name: | WD repeat and FYVE domain-containing protein 2 |
NCBI Synonym Full Names: | WD repeat and FYVE domain containing 2 |
NCBI Official Symbol: | WDFY2 |
NCBI Official Synonym Symbols: | PROF; WDF2; ZFYVE22 |
NCBI Protein Information: | WD repeat and FYVE domain-containing protein 2 |
UniProt Protein Name: | WD repeat and FYVE domain-containing protein 2 |
UniProt Synonym Protein Names: | Propeller-FYVE protein |
UniProt Gene Name: | WDFY2 |