UniProt Protein Function: | WAC: Acts as a linker between gene transcription and histone H2B monoubiquitination at 'Lys-120' (H2BK120ub1). Interacts with the RNA polymerase II transcriptional machinery via its WW domain and with RNF20-RNF40 via its coiled coil region, thereby linking and regulating H2BK120ub1 and gene transcription. Regulates the cell-cycle checkpoint activation in response to DNA damage. Positive regulator of amino acid starvation-induced autophagy. May negatively regulate the ubiquitin proteasome pathway. 4 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Adaptor/scaffold Chromosomal Location of Human Ortholog: 10p12.1|10p12.1-p11.2 Cellular Component: nucleoplasm; nucleus Molecular Function:chromatin binding; protein binding Biological Process: histone monoubiquitination; negative regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of macroautophagy; positive regulation of transcription, DNA-dependent; response to DNA damage stimulus |
NCBI Summary: | The protein encoded by this gene contains a WW domain, which is a protein module found in a wide range of signaling proteins. This domain mediates protein-protein interactions and binds proteins containing short linear peptide motifs that are proline-rich or contain at least one proline. This gene product shares 94% sequence identity with the WAC protein in mouse, however, its exact function is not known. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2008] |
UniProt Code: | Q9BTA9 |
NCBI GenInfo Identifier: | 117949358 |
NCBI Gene ID: | 51322 |
NCBI Accession: | Q9BTA9.3 |
UniProt Secondary Accession: | Q9BTA9,Q53EN9, Q5JU75, Q5JU77, Q5VXK0, Q5VXK2, Q8TCK1 A8K2A9, C9JBT9, D3DRW5, D3DRW6, D3DRW7, |
UniProt Related Accession: | Q9BTA9 |
Molecular Weight: | 59,505 Da |
NCBI Full Name: | WW domain-containing adapter protein with coiled-coil |
NCBI Synonym Full Names: | WW domain containing adaptor with coiled-coil |
NCBI Official Symbol: | WAC |
NCBI Official Synonym Symbols: | Wwp4; DESSH; BM-016; PRO1741 |
NCBI Protein Information: | WW domain-containing adapter protein with coiled-coil |
UniProt Protein Name: | WW domain-containing adapter protein with coiled-coil |
Protein Family: | Fibritin |
UniProt Gene Name: | WAC |
UniProt Entry Name: | WAC_HUMAN |