WAC Antibody, HRP conjugated (PACO47023)
- SKU:
- PACO47023
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- HRP
Frequently bought together:
Description
抗体名: | WAC Antibody, HRP conjugated (PACO47023) |
抗体コード: | PACO47023 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human WW domain-containing adapter protein with coiled-coil protein (10-102AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | HRP |
バックグラウンド: | Acts as a linker between gene transcription and histone H2B monoubiquitination at 'Lys-120' (H2BK120ub1). Interacts with the RNA polymerase II transcriptional machinery via its WW domain and with RNF20-RNF40 via its coiled coil region, thereby linking and regulating H2BK120ub1 and gene transcription. Regulates the cell-cycle checkpoint activation in response to DNA damage. Positive regulator of amino acid, starvation-induced autophagy. May negatively regulate the ubiquitin proteasome pathway. |
シノニム: | WW domain-containing adapter protein with coiled-coil, WAC, KIAA1844 |
UniProt Protein Function: | WAC: Acts as a linker between gene transcription and histone H2B monoubiquitination at 'Lys-120' (H2BK120ub1). Interacts with the RNA polymerase II transcriptional machinery via its WW domain and with RNF20-RNF40 via its coiled coil region, thereby linking and regulating H2BK120ub1 and gene transcription. Regulates the cell-cycle checkpoint activation in response to DNA damage. Positive regulator of amino acid starvation-induced autophagy. May negatively regulate the ubiquitin proteasome pathway. 4 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Adaptor/scaffold Chromosomal Location of Human Ortholog: 10p12.1|10p12.1-p11.2 Cellular Component: nucleoplasm; nucleus Molecular Function:chromatin binding; protein binding Biological Process: histone monoubiquitination; negative regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of macroautophagy; positive regulation of transcription, DNA-dependent; response to DNA damage stimulus |
NCBI Summary: | The protein encoded by this gene contains a WW domain, which is a protein module found in a wide range of signaling proteins. This domain mediates protein-protein interactions and binds proteins containing short linear peptide motifs that are proline-rich or contain at least one proline. This gene product shares 94% sequence identity with the WAC protein in mouse, however, its exact function is not known. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2008] |
UniProt Code: | Q9BTA9 |
NCBI GenInfo Identifier: | 117949358 |
NCBI Gene ID: | 51322 |
NCBI Accession: | Q9BTA9.3 |
UniProt Secondary Accession: | Q9BTA9,Q53EN9, Q5JU75, Q5JU77, Q5VXK0, Q5VXK2, Q8TCK1 A8K2A9, C9JBT9, D3DRW5, D3DRW6, D3DRW7, |
UniProt Related Accession: | Q9BTA9 |
Molecular Weight: | 59,505 Da |
NCBI Full Name: | WW domain-containing adapter protein with coiled-coil |
NCBI Synonym Full Names: | WW domain containing adaptor with coiled-coil |
NCBI Official Symbol: | WAC |
NCBI Official Synonym Symbols: | Wwp4; DESSH; BM-016; PRO1741 |
NCBI Protein Information: | WW domain-containing adapter protein with coiled-coil |
UniProt Protein Name: | WW domain-containing adapter protein with coiled-coil |
Protein Family: | Fibritin |
UniProt Gene Name: | WAC |
UniProt Entry Name: | WAC_HUMAN |