VCAM1 Antibody, HRP conjugated (PACO31045)
- SKU:
- PACO31045
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- HRP
Description
抗体名: | VCAM1 Antibody, HRP conjugated (PACO31045) |
抗体コード: | PACO31045 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Vascular cell adhesion protein 1 protein (25-698AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | HRP |
バックグラウンド: | Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with integrin alpha-4/beta-1 (ITGA4/ITGB1) on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/ITGA4/ITGB1 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation. |
シノニム: | Vascular cell adhesion protein 1 (V-CAM 1) (VCAM-1) (INCAM-100) (CD antigen CD106), VCAM1 |
UniProt Protein Function: | VCAM1: Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with the beta-1 integrin VLA4 on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/VLA4 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Membrane protein, integral; Motility/polarity/chemotaxis; Cell adhesion Chromosomal Location of Human Ortholog: 1p32-p31 Cellular Component: Golgi apparatus; extracellular space; cell surface; microvillus; endoplasmic reticulum; early endosome; integral to membrane; apical part of cell; plasma membrane; podosome; sarcolemma; filopodium; external side of plasma membrane Molecular Function:amine oxidase activity; integrin binding; cell adhesion molecule binding Biological Process: response to nicotine; regulation of immune response; chronic inflammatory response; extracellular matrix organization and biogenesis; viral reproduction; heart development; cytokine and chemokine mediated signaling pathway; cell-matrix adhesion; response to lipopolysaccharide; heterophilic cell adhesion; leukocyte adhesion; response to ethanol; response to zinc ion; B cell differentiation; membrane to membrane docking; response to hypoxia; positive regulation of T cell proliferation; amine metabolic process; response to ionizing radiation; cell adhesion; leukocyte tethering or rolling; acute inflammatory response; response to nutrient; aging |
NCBI Summary: | This gene is a member of the Ig superfamily and encodes a cell surface sialoglycoprotein expressed by cytokine-activated endothelium. This type I membrane protein mediates leukocyte-endothelial cell adhesion and signal transduction, and may play a role in the development of artherosclerosis and rheumatoid arthritis. Three alternatively spliced transcripts encoding different isoforms have been described for this gene. [provided by RefSeq, Dec 2010] |
UniProt Code: | P19320 |
NCBI GenInfo Identifier: | 137560 |
NCBI Gene ID: | 7412 |
NCBI Accession: | P19320.1 |
UniProt Secondary Accession: | P19320,Q6NUP8, A8K6R7, B4DKS4, E9PDD1, |
UniProt Related Accession: | P19320 |
Molecular Weight: | 74,346 Da |
NCBI Full Name: | Vascular cell adhesion protein 1 |
NCBI Synonym Full Names: | vascular cell adhesion molecule 1 |
NCBI Official Symbol: | VCAM1 |
NCBI Official Synonym Symbols: | CD106; INCAM-100 |
NCBI Protein Information: | vascular cell adhesion protein 1; CD106 antigen |
UniProt Protein Name: | Vascular cell adhesion protein 1 |
UniProt Synonym Protein Names: | INCAM-100; CD_antigen: CD106 |
Protein Family: | Vascular cell adhesion protein |
UniProt Gene Name: | VCAM1 |
UniProt Entry Name: | VCAM1_HUMAN |