VANGL1 Antibody (PACO15209)
- SKU:
- PACO15209
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | VANGL1 Antibody (PACO15209) |
抗体コード: | PACO15209 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IHC |
推奨される希釈: | ELISA:1:1000-1:2000, WB:1:200-1:1000, IHC:1:25-1:100 |
反応性: | Human, Mouse |
免疫原: | Fusion protein of human VANGL1 |
憲法: | Liquid |
ストレージバッファ: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
精製方法: | Antigen affinity purification |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
![]() | The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO15209(VANGL1 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: x200). |
![]() | Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Human lymphoma tissue, Human testis tissue, Primary antibody: PACO15209(VANGL1 Antibody) at dilution 1/250, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds. |
![]() | The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using PACO15209(VANGL1 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: x200). |
バックグラウンド: | This gene encodes a member of the tretraspanin family. The encoded protein may be involved in mediating intestinal trefoil factor induced wound healing in the intestinal mucosa. Mutations in this gene are associated with neural tube defects. Alternate splicing results in multiple transcript variants. Interacts through its C-terminal region with the N-terminal half of DVL1, DVL2 and DVL3. The PDZ domain of DVL1, DVL2 and DVL3 is required for the interaction. |
シノニム: | VANGL planar cell polarity protein 1 |
UniProt Protein Function: | VANGL1: Defects in VANGL1 are a cause of neural tube defects (NTD). NTD are congenital malformations. The most common forms of NTD are described as open defects (including anencephaly and myelomeningocele, or spina bifida), which result from the failure of fusion in the cranial and spinal region of the neural tube, respectively. Other open dysraphisms (including myeloschisis, hemimyelomeningocele, and hemimyelocele) are sometimes associated with a Chiari type 2 malformation. A number of skin-covered (closed) NTD are categorized clinically depending on the presence of a subcutaneous mass (lipomyeloschisis, lipomyelomeningocele, meningocele, and myelocystocele) or the absence of such a mass (complex dysraphic states, including split cord malformations, dermal sinus, caudal regression, and segmental spinal dysgenesis). Defects in VANGL1 are a cause of sacral defect with anterior meningocele (SDAM). SDAM is a form of caudal dysgenesis. It is present at birth and becomes symptomatic later in life, usually because of obstructive labor in females, chronic constipation, or meningitis. Inheritance is autosomal dominant. Belongs to the Vang family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Membrane protein, integral; Adaptor/scaffold; Membrane protein, multi-pass; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 1p13.1 Molecular Function:protein binding Disease: Neural Tube Defects; Sacral Defect With Anterior Meningocele |
NCBI Summary: | This gene encodes a member of the tretraspanin family. The encoded protein may be involved in mediating intestinal trefoil factor induced wound healing in the intestinal mucosa. Mutations in this gene are associated with neural tube defects. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010] |
UniProt Code: | Q8TAA9 |
NCBI GenInfo Identifier: | 40807121 |
NCBI Gene ID: | 81839 |
NCBI Accession: | BC065272 |
UniProt Secondary Accession: | Q8TAA9,Q5T1D3, Q5T1D4, Q86WG8, Q8N559, |
UniProt Related Accession: | Q8TAA9 |
Molecular Weight: | 59,748 Da |
NCBI Full Name: | Homo sapiens vang-like 1 (van gogh, Drosophila), mRNA |
NCBI Synonym Full Names: | VANGL planar cell polarity protein 1 |
NCBI Official Symbol: | VANGL1 |
NCBI Official Synonym Symbols: | LPP2; STB2; STBM2; KITENIN |
NCBI Protein Information: | vang-like protein 1 |
UniProt Protein Name: | Vang-like protein 1 |
UniProt Synonym Protein Names: | Loop-tail protein 2 homolog; LPP2; Strabismus 2; Van Gogh-like protein 1 |
Protein Family: | Vang-like protein |
UniProt Gene Name: | VANGL1 |
UniProt Entry Name: | VANG1_HUMAN |