USP36 Antibody (PACO63227)
- SKU:
- PACO63227
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | USP36 Antibody (PACO63227) |
抗体コード: | PACO63227 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, IHC |
推奨される希釈: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
反応性: | Human |
免疫原: | Recombinant Human Ubiquitin carboxyl-terminal hydrolase 36 protein (670-881AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | Antigen Affinity Purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
IHC image of PACO63227 diluted at 1:100 and staining in paraffin-embedded human liver cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. |
バックグラウンド: | May be required for maintaining multiple types of adult stem cells. May function as a transcriptional repressor by continually deubiquiting histone H2B at the promoters of genes critical for cellular differentiation, thereby preventing histone H3 'Lys-4' trimethylation (H3K4) (By similarity). |
シノニム: | Ubiquitin carboxyl-terminal hydrolase 36 (EC 3.4.19.12) (Deubiquitinating enzyme 36) (Ubiquitin thioesterase 36) (Ubiquitin-specific-processing protease 36), USP36, KIAA1453 |
UniProt Protein Function: | USP36: May be required for maintaining multiple types of adult stem cells. May function as a transcriptional repressor by continually deubiquiting histone H2B at the promoters of genes critical for cellular differentiation, thereby preventing histone H3 'Lys-4' trimethylation (H3K4). Belongs to the peptidase C19 family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Ubiquitin-specific protease; Ubiquitin conjugating system; EC 3.4.19.12; Nucleolus; Protease Chromosomal Location of Human Ortholog: 17q25.3 Cellular Component: nucleolus; nucleus Molecular Function:ubiquitin-specific protease activity Biological Process: protein deubiquitination; ubiquitin-dependent protein catabolic process |
NCBI Summary: | This gene encodes a member of the peptidase C19 or ubiquitin-specific protease family of cysteine proteases. Members of this family remove ubiquitin molecules from polyubiquitinated proteins. The encoded protein may deubiquitinate and stabilize the transcription factor c-Myc, also known as MYC, an important oncoprotein known to be upregulated in most human cancers. The encoded protease may also regulate the activation of autophagy. This gene exhibits elevated expression in some breast and lung cancers. [provided by RefSeq, Mar 2016] |
UniProt Code: | Q9P275 |
NCBI GenInfo Identifier: | 124056592 |
NCBI Gene ID: | 57602 |
NCBI Accession: | Q9P275.3 |
UniProt Secondary Accession: | Q9P275,Q05C98, Q05DD0, Q6IQ38, Q8NDM8, Q9NVC8, |
UniProt Related Accession: | Q9P275 |
Molecular Weight: | 122,908 Da |
NCBI Full Name: | Ubiquitin carboxyl-terminal hydrolase 36 |
NCBI Synonym Full Names: | ubiquitin specific peptidase 36 |
NCBI Official Symbol: | USP36 |
NCBI Official Synonym Symbols: | DUB1 |
NCBI Protein Information: | ubiquitin carboxyl-terminal hydrolase 36 |
UniProt Protein Name: | Ubiquitin carboxyl-terminal hydrolase 36 |
UniProt Synonym Protein Names: | Deubiquitinating enzyme 36; Ubiquitin thioesterase 36; Ubiquitin-specific-processing protease 36 |
Protein Family: | Ubiquitin carboxyl-terminal hydrolase |
UniProt Gene Name: | USP36 |
UniProt Entry Name: | UBP36_HUMAN |