USP33 Antibody, FITC conjugated (PACO38844)
- SKU:
- PACO38844
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- FITC
Frequently bought together:
Description
抗体名: | USP33 Antibody, FITC conjugated (PACO38844) |
抗体コード: | PACO38844 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Ubiquitin carboxyl-terminal hydrolase 33 protein (251-550AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | FITC |
バックグラウンド: | Deubiquitinating enzyme involved in various processes such as centrosome duplication, cellular migration and beta-2 adrenergic receptor/ADRB2 recycling. Involved in regulation of centrosome duplication by mediating deubiquitination of CCP110 in S and G2/M phase, leading to stabilize CCP110 during the period which centrioles duplicate and elongate. Involved in cell migration via its interaction with intracellular domain of ROBO1, leading to regulate the Slit signaling. Plays a role in commissural axon guidance cross the ventral midline of the neural tube in a Slit-dependent manner, possibly by mediating the deubiquitination of ROBO1. Acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination of beta-arrestins (ARRB1 and ARRB2) and beta-2 adrenergic receptor (ADRB2). Plays a central role in ADRB2 recycling and resensitization after prolonged agonist stimulation by constitutively binding ADRB2, mediating deubiquitination of ADRB2 and inhibiting lysosomal trafficking of ADRB2. Upon dissociation, it is probably transferred to the translocated beta-arrestins, leading to beta-arrestins deubiquitination and disengagement from ADRB2. This suggests the existence of a dynamic exchange between the ADRB2 and beta-arrestins. Deubiquitinates DIO2, thereby regulating thyroid hormone regulation. Mediates deubiquitination of both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. |
シノニム: | Ubiquitin carboxyl-terminal hydrolase 33 (EC 3.4.19.12) (Deubiquitinating enzyme 33) (Ubiquitin thioesterase 33) (Ubiquitin-specific-processing protease 33) (VHL-interacting deubiquitinating enzyme 1) (hVDU1), USP33, KIAA1097 VDU1 |
NCBI Summary: | This gene encodes a deubiquinating enzyme important in a variety of processes, including Slit-dependent cell migration and beta-2 adrenergic receptor signaling. The protein is negatively regulated through ubiquitination by von Hippel-Lindau tumor protein (VHL). Alternative splicing results in multiple transcript variants and protein isoforms. [provided by RefSeq, Jun 2012] |
UniProt Code: | Q8TEY7 |
NCBI GenInfo Identifier: | 42516567 |
NCBI Gene ID: | 23032 |
NCBI Accession: | NP_055832.3 |
UniProt Secondary Accession: | Q8TEY7,A6QNM7, Q8TEY6, |
UniProt Related Accession: | Q8TEY7 |
Molecular Weight: | |
NCBI Full Name: | ubiquitin carboxyl-terminal hydrolase 33 isoform 1 |
NCBI Synonym Full Names: | ubiquitin specific peptidase 33 |
NCBI Official Symbol: | USP33 |
NCBI Official Synonym Symbols: | VDU1 |
NCBI Protein Information: | ubiquitin carboxyl-terminal hydrolase 33 |
UniProt Protein Name: | Ubiquitin carboxyl-terminal hydrolase 33 |
UniProt Synonym Protein Names: | Ubiquitin thiolesterase 33; Ubiquitin-specific-processing protease 33; Deubiquitinating enzyme 33; VHL-interacting deubiquitinating enzyme 1 |
UniProt Gene Name: | USP33 |
UniProt Entry Name: | UBP33_HUMAN |