UPF2 Antibody (PACO44530)
- SKU:
- PACO44530
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | UPF2 Antibody (PACO44530) |
抗体コード: | PACO44530 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, IHC |
推奨される希釈: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
反応性: | Human |
免疫原: | Recombinant Human Regulator of nonsense transcripts 2 protein (1153-1272AA) |
憲法: | Liquid |
ストレージバッファ: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
精製方法: | Antigen Affinity Purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
Immunohistochemistry of paraffin-embedded human liver cancer using PACO44530 at dilution of 1:100. |
バックグラウンド: | Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex (EJC). Recruited by UPF3B associated with the EJC core at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2-UPF3 surveillance complex (including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. In cooperation with UPF3B stimulates both ATPase and RNA helicase activities of UPF1. Binds spliced mRNA. |
シノニム: | Regulator of nonsense transcripts 2 (Nonsense mRNA reducing factor 2) (Up-frameshift suppressor 2 homolog) (hUpf2), UPF2, KIAA1408 RENT2 |
UniProt Protein Function: | UPF2: Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex (EJC). Recruited by UPF3B associated with the EJC core at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2-UPF3 surveillance complex (including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. In cooperation with UPF3B stimulates both ATPase and RNA helicase activities of UPF1. Binds spliced mRNA. Found in a post-splicing messenger ribonucleoprotein (mRNP) complex. Associates with the exon junction complex (EJC). Interacts with SMG1, EST1A, UPF1, UPF3A, UPF3B, EIF4A1 and EIF1. Ubiquitous. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:RNA-binding Chromosomal Location of Human Ortholog: 10p14-p13 Cellular Component: cytoplasm; cytosol; nucleus Molecular Function:protein binding; telomeric DNA binding Biological Process: mRNA catabolic process, nonsense-mediated decay; mRNA export from nucleus |
NCBI Summary: | This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein is located in the perinuclear area. It interacts with translation release factors and the proteins that are functional homologs of yeast Upf1p and Upf3p. Two splice variants have been found for this gene; both variants encode the same protein. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q9HAU5 |
NCBI GenInfo Identifier: | 60390647 |
NCBI Gene ID: | 26019 |
NCBI Accession: | Q9HAU5.1 |
UniProt Secondary Accession: | Q9HAU5,Q14BM1, Q5W0J4, Q8N8U1, Q9H1J2, Q9NWL1, Q9P2D9 Q9Y4M9, A6NLJ5, D3DRS0, |
UniProt Related Accession: | Q9HAU5 |
Molecular Weight: | 66,842 Da |
NCBI Full Name: | Regulator of nonsense transcripts 2 |
NCBI Synonym Full Names: | UPF2 regulator of nonsense transcripts homolog (yeast) |
NCBI Official Symbol: | UPF2 |
NCBI Official Synonym Symbols: | HUPF2; RENT2; smg-3 |
NCBI Protein Information: | regulator of nonsense transcripts 2 |
UniProt Protein Name: | Regulator of nonsense transcripts 2 |
UniProt Synonym Protein Names: | Nonsense mRNA reducing factor 2; Up-frameshift suppressor 2 homolog; hUpf2 |
Protein Family: | Regulator of nonsense transcripts |
UniProt Gene Name: | UPF2 |
UniProt Entry Name: | RENT2_HUMAN |