ULK2 Antibody, HRP conjugated (PACO59222)
- SKU:
- PACO59222
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- HRP
Frequently bought together:
Description
抗体名: | ULK2 Antibody, HRP conjugated (PACO59222) |
抗体コード: | PACO59222 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Serine/threonine-protein kinase ULK2 protein (211-276AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | HRP |
バックグラウンド: | Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and a negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK, also acts as a negative regulator of AMPK through phosphorylation of the AMPK subunits PRKAA1, PRKAB2 and PRKAG1. May phosphorylate ATG13/KIAA0652, FRS2, FRS3 and RPTOR; however such data need additional evidences. Not involved in ammonia-induced autophagy or in autophagic response of cerebellar granule neurons (CGN) to low potassium concentration. Plays a role early in neuronal differentiation and is required for granule cell axon formation: may govern axon formation via Ras-like GTPase signaling and through regulation of the Rab5-mediated endocytic pathways within developing axons. |
シノニム: | Serine/threonine-protein kinase ULK2 (EC 2.7.11.1) (Unc-51-like kinase 2), ULK2, KIAA0623 |
UniProt Protein Function: | ULK2: Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3- kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and a negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK, also acts as a negative regulator of AMPK through phosphorylation of the AMPK subunits PRKAA1, PRKAB2 and PRKAG1. May phosphorylate ATG13/KIAA0652, FRS2, FRS3 and RPTOR; however such data need additional evidences. Not involved in ammonia-induced autophagy or in autophagic response of cerebellar granule neurons (CGN) to low potassium concentration. Plays a role early in neuronal differentiation and is required for granule cell axon formation: may govern axon formation via Ras-like GTPase signaling and through regulation of the Rab5-mediated endocytic pathways within developing axons. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily. |
UniProt Protein Details: | Protein type:Kinase, protein; Autophagy; EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); Protein kinase, Other; Other group; ULK family Chromosomal Location of Human Ortholog: 17p11.2 Cellular Component: pre-autophagosomal structure membrane Molecular Function:protein binding; protein serine/threonine kinase activity Biological Process: axon extension; protein amino acid autophosphorylation; regulation of autophagy; response to starvation |
NCBI Summary: | This gene encodes a protein that is similar to a serine/threonine kinase in C. elegans which is involved in axonal elongation. The structure of this protein is similar to the C. elegans protein in that both proteins have an N-terminal kinase domain, a central proline/serine rich (PS) domain, and a C-terminal (C) domain. The gene is located within the Smith-Magenis syndrome region on chromosome 17. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Dec 2008] |
UniProt Code: | Q8IYT8 |
NCBI GenInfo Identifier: | 296453001 |
NCBI Gene ID: | 9706 |
NCBI Accession: | Q8IYT8.3 |
UniProt Secondary Accession: | Q8IYT8,O75119, A8MY69, |
UniProt Related Accession: | Q8IYT8 |
Molecular Weight: | 112,694 Da |
NCBI Full Name: | Serine/threonine-protein kinase ULK2 |
NCBI Synonym Full Names: | unc-51 like autophagy activating kinase 2 |
NCBI Official Symbol: | ULK2 |
NCBI Official Synonym Symbols: | ATG1B; Unc51.2 |
NCBI Protein Information: | serine/threonine-protein kinase ULK2 |
UniProt Protein Name: | Serine/threonine-protein kinase ULK2 |
UniProt Synonym Protein Names: | Unc-51-like kinase 2 |
Protein Family: | Serine/threonine-protein kinase |
UniProt Gene Name: | ULK2 |
UniProt Entry Name: | ULK2_HUMAN |