UGDH Antibody (PACO30988)
- SKU:
- PACO30988
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | UGDH Antibody (PACO30988) |
抗体コード: | PACO30988 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human UDP-glucose 6-dehydrogenase protein (1-494AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
バックグラウンド: | Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate, and heparan sulfate. |
シノニム: | UDP-glucose 6-dehydrogenase (UDP-Glc dehydrogenase) (UDP-GlcDH) (UDPGDH) (EC 1.1.1.22), UGDH |
UniProt Protein Function: | UGDH: Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate, and heparan sulfate. Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Oxidoreductase; Motility/polarity/chemotaxis; Carbohydrate Metabolism - starch and sucrose; EC 1.1.1.22; Carbohydrate Metabolism - ascorbate and aldarate; Carbohydrate Metabolism - amino sugar and nucleotide sugar; Carbohydrate Metabolism - pentose and glucuronate interconversions Chromosomal Location of Human Ortholog: 4p15.1 Cellular Component: nucleoplasm; cytosol Molecular Function:electron carrier activity; NAD binding; UDP-glucose 6-dehydrogenase activity Biological Process: glycosaminoglycan biosynthetic process; xenobiotic metabolic process; gastrulation with mouth forming second; UDP-glucuronate biosynthetic process; UDP-glucose metabolic process |
NCBI Summary: | The protein encoded by this gene converts UDP-glucose to UDP-glucuronate and thereby participates in the biosynthesis of glycosaminoglycans such as hyaluronan, chondroitin sulfate, and heparan sulfate. These glycosylated compounds are common components of the extracellular matrix and likely play roles in signal transduction, cell migration, and cancer growth and metastasis. The expression of this gene is up-regulated by transforming growth factor beta and down-regulated by hypoxia. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010] |
UniProt Code: | O60701 |
NCBI GenInfo Identifier: | 6175086 |
NCBI Gene ID: | 7358 |
NCBI Accession: | O60701.1 |
UniProt Secondary Accession: | O60701,O60589, B3KUU2, B4DN25, |
UniProt Related Accession: | O60701 |
Molecular Weight: | 494 |
NCBI Full Name: | UDP-glucose 6-dehydrogenase |
NCBI Synonym Full Names: | UDP-glucose 6-dehydrogenase |
NCBI Official Symbol: | UGDH |
NCBI Official Synonym Symbols: | GDH; UGD; UDPGDH; UDP-GlcDH |
NCBI Protein Information: | UDP-glucose 6-dehydrogenase; UDP-Glc dehydrogenase; UDP-glucose dehydrogenase; uridine diphospho-glucose dehydrogenase |
UniProt Protein Name: | UDP-glucose 6-dehydrogenase |
UniProt Gene Name: | UGDH |
UniProt Entry Name: | UGDH_HUMAN |