UBE2O Antibody, FITC conjugated (PACO40764)
- SKU:
- PACO40764
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- FITC
Frequently bought together:
Description
抗体名: | UBE2O Antibody, FITC conjugated (PACO40764) |
抗体コード: | PACO40764 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human (E3-independent) E2 ubiquitin-conjugating enzyme protein (10-277AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | Antigen Affinity Purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | FITC |
バックグラウンド: | E2/E3 hybrid ubiquitin-protein ligase that displays both E2 and E3 ligase activities and mediates monoubiquitination of target proteins. Negatively regulates TRAF6-mediated NF-kappa-B activation independently of its E2 activity. Acts as a positive regulator of BMP7 signaling by mediating monoubiquitination of SMAD6, thereby regulating adipogenesis. Mediates monoubiquitination at different sites of the nuclear localization signal (NLS) of BAP1, leading to cytoplasmic retention of BAP1. Also able to monoubiquitinate the NLS of other chromatin-associated proteins, such as INO80 and CXXC1, affecting their subcellular location. Acts as a regulator of retrograde transport by assisting the TRIM27:MAGEL2 E3 ubiquitin ligase complex to mediate 'Lys-63'-linked ubiquitination of WASH1, leading to promote endosomal F-actin assembly. |
シノニム: | (E3-independent) E2 ubiquitin-conjugating enzyme (EC 2.3.2.24) (E2/E3 hybrid ubiquitin-protein ligase UBE2O) (Ubiquitin carrier protein O) (Ubiquitin-conjugating enzyme E2 O) (Ubiquitin-conjugating enzyme E2 of 230 kDa) (Ubiquitin-conjugating enzyme E2-230K) (Ubiquitin-protein ligase O), UBE2O, KIAA1734 |
UniProt Protein Function: | UBE2O: Catalyzes the covalent attachment of ubiquitin to other proteins. Belongs to the ubiquitin-conjugating enzyme family. |
UniProt Protein Details: | Protein type:EC 6.3.2.19; Ubiquitin conjugating system; Ubiquitin ligase; Ligase Chromosomal Location of Human Ortholog: 17q25.1 Cellular Component: nucleoplasm; cytoplasm; nucleus Molecular Function:protein binding; small conjugating protein ligase activity; ubiquitin protein ligase binding; ubiquitin-protein ligase activity; ATP binding; ligase activity Biological Process: protein monoubiquitination; retrograde transport, endosome to Golgi; positive regulation of BMP signaling pathway |
UniProt Code: | Q9C0C9 |
NCBI GenInfo Identifier: | 192449449 |
NCBI Gene ID: | 63893 |
NCBI Accession: | NP_071349.3 |
UniProt Secondary Accession: | Q9C0C9,Q69YP4, Q6PIZ2, Q86UA4, Q8N425, Q8TBN1, Q9BSW1 Q9H6E6, Q9H7E4, Q9H9B2, A6NDU5, |
UniProt Related Accession: | Q9C0C9 |
Molecular Weight: | |
NCBI Full Name: | ubiquitin-conjugating enzyme E2 O |
NCBI Synonym Full Names: | ubiquitin-conjugating enzyme E2O |
NCBI Official Symbol: | UBE2O |
NCBI Official Synonym Symbols: | E2-230K |
NCBI Protein Information: | E2/E3 hybrid ubiquitin-protein ligase UBE2O; ubiquitin-protein ligase O; ubiquitin carrier protein O; ubiquitin-conjugating enzyme E2-230K; ubiquitin-conjugating enzyme E2 of 230 kDa |
UniProt Protein Name: | E2/E3 hybrid ubiquitin-protein ligase UBE2O |
UniProt Synonym Protein Names: | Ubiquitin carrier protein O; Ubiquitin-conjugating enzyme E2 O; Ubiquitin-conjugating enzyme E2 of 230 kDa; Ubiquitin-conjugating enzyme E2-230K; Ubiquitin-protein ligase O |
Protein Family: | (E3-independent) E2 ubiquitin-conjugating enzyme |
UniProt Gene Name: | UBE2O |
UniProt Entry Name: | UBE2O_HUMAN |