TUSC3 Antibody (PACO58965)
- SKU:
- PACO58965
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | TUSC3 Antibody (PACO58965) |
抗体コード: | PACO58965 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IHC |
推奨される希釈: | ELISA:1:2000-1:10000, WB:1:500-1:5000, IHC:1:200-1:500 |
反応性: | Human, Rat |
免疫原: | Recombinant Human Tumor suppressor candidate 3 protein (42-196AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
![]() | Western Blot. Positive WB detected in: Rat lung tissue, Rat heart tissue. All lanes: TUSC3 antibody at 4.7µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 40 kDa. Observed band size: 40 kDa. |
![]() | IHC image of PACO58965 diluted at 1:300 and staining in paraffin-embedded human testis tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. |
![]() | IHC image of PACO58965 diluted at 1:300 and staining in paraffin-embedded human small intestine tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. |
バックグラウンド: | Acts as accessory component of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. Involved in N-glycosylation of STT3B-dependent substrates. Specifically required for the glycosylation of a subset of acceptor sites that are near cysteine residues; in this function seems to act redundantly with MAGT1. In its oxidized form proposed to form transient mixed disulfides with a glycoprotein substrate to facilitate access of STT3B to the unmodified acceptor site. Has also oxidoreductase-independent functions in the STT3B-containing OST complex possibly involving substrate recognition. |
シノニム: | Tumor suppressor candidate 3 (Magnesium uptake/transporter TUSC3) (Protein N33), TUSC3, N33 |
UniProt Protein Function: | TUSC3: Magnesium transporter. May be involved in N- glycosylation through its association with N-oligosaccharyl transferase. Defects in TUSC3 are the cause of mental retardation autosomal recessive type 7 (MRT7); also known as mental retardation non-syndromic autosomal recessive 7. Mental retardation is characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. Non- syndromic mental retardation patients do not manifest other clinical signs. Belongs to the OST3/OST6 family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Membrane protein, integral; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 8p22 Cellular Component: endoplasmic reticulum membrane; mitochondrion; oligosaccharyl transferase complex; plasma membrane Molecular Function:dolichyl-diphosphooligosaccharide-protein glycotransferase activity; magnesium ion transmembrane transporter activity Biological Process: cognition; magnesium ion transport; protein amino acid N-linked glycosylation via asparagine; transmembrane transport Disease: Mental Retardation, Autosomal Recessive 7 |
NCBI Summary: | This gene is a candidate tumor suppressor gene. It is located within a homozygously deleted region of a metastatic prostate cancer. The gene is expressed in most nonlymphoid human tissues including prostate, lung, liver, and colon. Expression was also detected in many epithelial tumor cell lines. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q13454 |
NCBI GenInfo Identifier: | 6166601 |
NCBI Gene ID: | 7991 |
NCBI Accession: | Q13454.1 |
UniProt Secondary Accession: | Q13454,Q14911, Q14912, Q96FW0, A8MSM0, D3DSP2, |
UniProt Related Accession: | Q13454 |
Molecular Weight: | 40kDa |
NCBI Full Name: | Tumor suppressor candidate 3 |
NCBI Synonym Full Names: | tumor suppressor candidate 3 |
NCBI Official Symbol: | TUSC3 |
NCBI Official Synonym Symbols: | M33; N33; MRT7; MRT22; OST3A; D8S1992 |
NCBI Protein Information: | tumor suppressor candidate 3 |
UniProt Protein Name: | Tumor suppressor candidate 3 |
UniProt Synonym Protein Names: | Magnesium uptake/transporter TUSC3; Protein N33 |
Protein Family: | Tumor suppressor candidate |
UniProt Gene Name: | TUSC3 |
Antibodies | ELISA Kits |
Anti-TUSC3 Antibody (CAB12571) | TUSC3 Colorimetric Cell-Based ELISA |
Anti-TUSC3 Antibody (CAB12728) | |
TUSC3 Antibody (PACO06668) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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