TTF1 Antibody, FITC conjugated (PACO33098)
- SKU:
- PACO33098
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- FITC
Frequently bought together:
Description
抗体名: | TTF1 Antibody, FITC conjugated (PACO33098) |
抗体コード: | PACO33098 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Transcription termination factor 1 protein (12-232AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | FITC |
バックグラウンド: | Multifunctional nucleolar protein that terminates ribosomal gene transcription, mediates replication fork arrest and regulates RNA polymerase I transcription on chromatin. Plays a dual role in rDNA regulation, being involved in both activation and silencing of rDNA transcription. Interaction with BAZ2A/TIP5 recovers DNA-binding activity. |
シノニム: | Transcription termination factor 1 (TTF-1) (RNA polymerase I termination factor) (Transcription termination factor I) (TTF-I), TTF1 |
UniProt Protein Function: | TTF1: Multifunctional nucleolar protein that terminates ribosomal gene transcription, mediates replication fork arrest and regulates RNA polymerase I transcription on chromatin. Plays a dual role in rDNA regulation, being involved in both activation and silencing of rDNA transcription. Interaction with BAZ2A/TIP5 recovers DNA-binding activity. |
UniProt Protein Details: | Protein type:Nucleolus; DNA-binding Chromosomal Location of Human Ortholog: 9q34.13 Cellular Component: cytoplasm; nucleolus; nucleoplasm; nucleus; plasma membrane Molecular Function:chromatin binding; DNA binding Biological Process: cellular protein metabolic process; chromatin remodeling; gene expression; negative regulation of DNA replication; negative regulation of gene expression, epigenetic; regulation of gene expression, epigenetic; regulation of transcription, DNA-dependent; termination of RNA polymerase I transcription; transcription from RNA polymerase I promoter; transcription initiation from RNA polymerase I promoter; transcription termination |
NCBI Summary: | This gene encodes a transcription termination factor that is localized to the nucleolus and plays a critical role in ribosomal gene transcription. The encoded protein mediates the termination of RNA polymerase I transcription by binding to Sal box terminator elements downstream of pre-rRNA coding regions. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. This gene shares the symbol/alias 'TFF1' with another gene, NK2 homeobox 1, also known as thyroid transcription factor 1, which plays a role in the regulation of thyroid-specific gene expression. [provided by RefSeq, Apr 2011] |
UniProt Code: | Q15361 |
NCBI GenInfo Identifier: | 328927005 |
NCBI Gene ID: | 7270 |
NCBI Accession: | NP_001192225.1 |
UniProt Secondary Accession: | Q15361,Q4VXF3, Q58EY2, Q6P5T5, A1L160, |
UniProt Related Accession: | Q15361 |
Molecular Weight: | 103,051 Da |
NCBI Full Name: | transcription termination factor 1 isoform 2 |
NCBI Synonym Full Names: | transcription termination factor, RNA polymerase I |
NCBI Official Symbol: | TTF1 |
NCBI Official Synonym Symbols: | TTF-1; TTF-I |
NCBI Protein Information: | transcription termination factor 1 |
UniProt Protein Name: | Transcription termination factor 1 |
UniProt Synonym Protein Names: | RNA polymerase I termination factor; Transcription termination factor I; TTF-I |
Protein Family: | Transcription termination factor |
UniProt Gene Name: | TTF1 |
UniProt Entry Name: | TTF1_HUMAN |