TSN Antibody (PACO01651)
- SKU:
- PACO01651
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | TSN Antibody |
抗体コード: | PACO01651 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IHC |
推奨される希釈: | WB:1:500-1:2000, IHC:1:100-1:300 |
反応性: | Human, Mouse, Rat |
免疫原: | synthesized peptide derived from the Internal region of human Translin. |
憲法: | Liquid |
ストレージバッファ: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
精製方法: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
シノニム: | TSN; Translin; Component 3 of promoter of RISC; C3PO |
UniProt Protein Function: | TSN: DNA-binding protein that specifically recognizes consensus sequences at the breakpoint junctions in chromosomal translocations, mostly involving immunoglobulin (Ig)/T-cell receptor gene segments. Seems to recognize single-stranded DNA ends generated by staggered breaks occurring at recombination hot spots. Belongs to the translin family. |
UniProt Protein Details: | Protein type:DNA-binding; Nuclear receptor co-regulator; EC 3.1.-.- Chromosomal Location of Human Ortholog: 2q21.1 Cellular Component: cytosol Molecular Function:DNA binding; protein binding Biological Process: DNA recombination; RNA-mediated gene silencing |
NCBI Summary: | This gene encodes a DNA-binding protein which specifically recognizes conserved target sequences at the breakpoint junction of chromosomal translocations. Translin polypeptides form a multimeric structure that is responsible for its DNA-binding activity. Recombination-associated motifs and translin-binding sites are present at recombination hotspots and may serve as indicators of breakpoints in genes which are fused by translocations. These binding activities may play a crucial role in chromosomal translocation in lymphoid neoplasms. This protein encoded by this gene, when complexed with translin-associated protein X, also forms a Mg ion-dependent endoribonuclease that promotes RNA-induced silencing complex (RISC) activation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2012] |
UniProt Code: | Q15631 |
NCBI GenInfo Identifier: | 6136060 |
NCBI Gene ID: | 7247 |
NCBI Accession: | Q15631.1 |
UniProt Secondary Accession: | Q15631,Q5U0K7, B7Z3X8, |
UniProt Related Accession: | Q15631 |
Molecular Weight: | 17,279 Da |
NCBI Full Name: | Translin |
NCBI Synonym Full Names: | translin |
NCBI Official Symbol: | TSN |
NCBI Official Synonym Symbols: | C3PO; RCHF1; TBRBP; TRSLN; BCLF-1; REHF-1 |
NCBI Protein Information: | translin |
UniProt Protein Name: | Translin |
UniProt Synonym Protein Names: | Component 3 of promoter of RISC; C3PO |
Protein Family: | Translin |
UniProt Gene Name: | TSN |
UniProt Entry Name: | TSN_HUMAN |