TRPM1 Antibody (PACO60188)
- SKU:
- PACO60188
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | TRPM1 Antibody (PACO60188) |
抗体コード: | PACO60188 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA, IF |
推奨される希釈: | ELISA:1:2000-1:10000, IF:1:50-1:200 |
反応性: | Human |
免疫原: | Recombinant Human Transient receptor potential cation channel subfamily M member 1 protein (1-97AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
![]() | Immunofluorescence staining of A549 cells with PACO60188 at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
バックグラウンド: | Cation channel essential for the depolarizing photoresponse of retinal ON bipolar cells. It is part of the GRM6 signaling cascade. May play a role in metastasis suppression (By similarity). May act as a spontaneously active, calcium-permeable plasma membrane channel. |
シノニム: | Transient receptor potential cation channel subfamily M member 1 (Long transient receptor potential channel 1) (LTrpC1) (Melastatin-1), TRPM1, LTRPC1 MLSN MLSN1 |
UniProt Protein Function: | TRPM1: a transient receptor potential (TRP) ion channel. TRP voltage-independent calcium-permeable cation channels are divided into six subfamilies, two of which (TRPC and TRPM) have members that are widely expressed. Its expression is inversely correlated with melanoma aggressiveness, suggesting that it suppresses melanoma metastasis. |
UniProt Protein Details: | Protein type:Membrane protein, integral; Channel, calcium; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 15q13.3 Cellular Component: integral to plasma membrane; plasma membrane Molecular Function:calcium channel activity Biological Process: metabotropic glutamate receptor signaling pathway; transport; visual perception Disease: Night Blindness, Congenital Stationary, Type 1c |
NCBI Summary: | This gene encodes a member of the transient receptor potential melastatin subfamily of transient receptor potential ion channels. The encoded protein is a calcium permeable cation channel that is expressed in melanocytes and may play a role in melanin synthesis. Specific mutations in this gene are the cause autosomal recessive complete congenital stationary night blindness-1C. The expression of this protein is inversely correlated with melanoma aggressiveness and as such it is used as a prognostic marker for melanoma metastasis. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2011] |
UniProt Code: | Q7Z4N2 |
NCBI GenInfo Identifier: | 34849477 |
NCBI Gene ID: | 4308 |
NCBI Accession: | BC058286 |
UniProt Secondary Accession: | Q7Z4N2,O75560, Q6PE48, Q7Z4N1, Q7Z4N3, Q7Z4N4, Q7Z4N5 D9IDV2, D9IDV3, F8W865, H0YN37, |
UniProt Related Accession: | Q7Z4N2 |
Molecular Weight: | 15,099 Da |
NCBI Full Name: | Homo sapiens transient receptor potential cation channel, subfamily M, member 1, mRNA |
NCBI Synonym Full Names: | transient receptor potential cation channel subfamily M member 1 |
NCBI Official Symbol: | TRPM1 |
NCBI Official Synonym Symbols: | MLSN1; CSNB1C; LTRPC1 |
NCBI Protein Information: | transient receptor potential cation channel subfamily M member 1 |
UniProt Protein Name: | Transient receptor potential cation channel subfamily M member 1 |
UniProt Synonym Protein Names: | Long transient receptor potential channel 1; LTrpC1; Melastatin-1 |
Protein Family: | Transient receptor potential cation channel subfamily |
UniProt Gene Name: | TRPM1 |
UniProt Entry Name: | TRPM1_HUMAN |
Antibodies |
Anti-TRPM1 Antibody (CAB17509) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |