TRIP4 Antibody, Biotin conjugated (PACO52349)
- SKU:
- PACO52349
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- Biotin
Frequently bought together:
Description
抗体名: | TRIP4 Antibody, Biotin conjugated (PACO52349) |
抗体コード: | PACO52349 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Activating signal cointegrator 1 protein (360-535AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Biotin |
バックグラウンド: | Transcription coactivator which associates with nuclear receptors, transcriptional coactivators including EP300, CREBBP and NCOA1, and basal transcription factors like TBP and TFIIA to facilitate nuclear receptors-mediated transcription. May thereby play an important role in establishing distinct coactivator complexes under different cellular conditions. Plays a role in thyroid hormone receptor and estrogen receptor transactivation. Also involved in androgen receptor transactivation (By similarity). Plays a pivotal role in the transactivation of NF-kappa-B, SRF and AP1. Acts as a mediator of transrepression between nuclear receptor and either AP1 or NF-kappa-B. May play a role in the development of neuromuscular junction. |
シノニム: | Activating signal cointegrator 1 (ASC-1) (Thyroid receptor-interacting protein 4) (TR-interacting protein 4) (TRIP-4), TRIP4 |
UniProt Protein Function: | TRIP4: thyroid receptor interacting protein 4 is a transcription coactivator of nuclear receptors including thyroid hormone receptor. Functions in conjunction with CBP-p300 and SRC-1. Plays a pivotal role in the transactivation of NF-kappa-B, SRF and AP1. Acts as a mediator of transrepression between nuclear receptor and either AP1 or NF-kappa-B. Plays a role in androgen receptor transactivation and in testicular function |
UniProt Protein Details: | Protein type:Transcription, coactivator/corepressor; Nuclear receptor co-regulator Chromosomal Location of Human Ortholog: 15q22.31 Cellular Component: cytoplasm; cytosol; microtubule organizing center; nucleoplasm; nucleus Molecular Function:estrogen receptor binding; histone acetyltransferase binding; ligand-dependent nuclear receptor binding; protease binding; protein binding; transcription coactivator activity; zinc ion binding Biological Process: estrogen receptor signaling pathway; positive regulation of transcription, DNA-dependent; transcription from RNA polymerase II promoter |
NCBI Summary: | This gene encodes a subunit of the tetrameric nuclear activating signal cointegrator 1 (ASC-1) complex, which associates with transcriptional coactivators, nuclear receptors and basal transcription factors to facilitate nuclear receptors-mediated transcription. This protein is localized in the nucleus and contains an E1A-type zinc finger domain, which mediates interaction with transcriptional coactivators and ligand-bound nuclear receptors, such as thyroid hormone receptor and retinoid X receptor alpha, but not glucocorticoid receptor. Mutations in this gene are associated with spinal muscular atrophy with congenital bone fractures-1 (SMABF1). [provided by RefSeq, Apr 2016] |
UniProt Code: | Q15650 |
NCBI GenInfo Identifier: | 116242828 |
NCBI Gene ID: | 9325 |
NCBI Accession: | Q15650.4 |
UniProt Secondary Accession: | Q15650,Q96ED7, Q9UKH0, B2RAS0, |
UniProt Related Accession: | Q15650 |
Molecular Weight: | 66,146 Da |
NCBI Full Name: | Activating signal cointegrator 1 |
NCBI Synonym Full Names: | thyroid hormone receptor interactor 4 |
NCBI Official Symbol: | TRIP4 |
NCBI Official Synonym Symbols: | ASC1; ASC-1; SMABF1; ZC2HC5; HsT17391 |
NCBI Protein Information: | activating signal cointegrator 1 |
UniProt Protein Name: | Activating signal cointegrator 1 |
UniProt Synonym Protein Names: | Thyroid receptor-interacting protein 4 |
Protein Family: | Activating signal cointegrator |
UniProt Gene Name: | TRIP4 |
UniProt Entry Name: | TRIP4_HUMAN |