TRIP10 Antibody (PACO53470)
- SKU:
- PACO53470
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | TRIP10 Antibody (PACO53470) |
抗体コード: | PACO53470 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA, IHC, IF |
推奨される希釈: | ELISA:1:2000-1:10000, IHC:1:20-1:200, IF:1:50-1:200 |
反応性: | Human |
免疫原: | Recombinant Human Cdc42-interacting protein 4 protein (276-486AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
Immunohistochemistry of paraffin-embedded human pancreatic tissue using PACO53470 at dilution of 1:100. | |
Immunofluorescent analysis of PC-3 cells using PACO53470 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). | |
Immunohistochemistry of paraffin-embedded human skeletal muscle tissue using PACO53470 at dilution of 1:100. |
バックグラウンド: | Required for translocation of GLUT4 to the plasma membrane in response to insulin signaling (By similarity). Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by recruiting WASL/N-WASP which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Required for the formation of podosomes, actin-rich adhesion structures specific to monocyte-derived cells. May be required for the lysosomal retention of FASLG/FASL. |
シノニム: | Cdc42-interacting protein 4 (Protein Felic) (Salt tolerant protein) (hSTP) (Thyroid receptor-interacting protein 10) (TR-interacting protein 10) (TRIP-10), TRIP10, CIP4 STOT STP |
UniProt Protein Function: | TRIP10: Required for translocation of GLUT4 to the plasma membrane in response to insulin signaling. Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by recruiting WASL/N- WASP which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Required for the formation of podosomes, actin-rich adhesion structures specific to monocyte-derived cells. May be required for the lysosomal retention of FASLG/FASL. Belongs to the FNBP1 family. 5 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Adaptor/scaffold; Nuclear receptor co-regulator Chromosomal Location of Human Ortholog: 19p13.3 Cellular Component: nucleoplasm; Golgi apparatus; cell projection; cytoskeleton; intracellular membrane-bound organelle; lysosome; perinuclear region of cytoplasm; cytoplasm; cell cortex; cytosol; phagocytic cup Molecular Function:identical protein binding; protein binding; lipid binding Biological Process: regulation of small GTPase mediated signal transduction; small GTPase mediated signal transduction; endocytosis; cell communication; actin cytoskeleton organization and biogenesis; signal transduction |
UniProt Code: | Q15642 |
NCBI GenInfo Identifier: | 118572632 |
NCBI Gene ID: | 9322 |
NCBI Accession: | Q15642.3 |
UniProt Related Accession: | Q15642 |
Molecular Weight: | 39kDa; 52kDa; 62kDa; 67kDa; 68kDa |
NCBI Full Name: | Cdc42-interacting protein 4 |
NCBI Synonym Full Names: | thyroid hormone receptor interactor 10 |
NCBI Official Symbol: | TRIP10 |
NCBI Official Synonym Symbols: | STP; CIP4; HSTP; STOT; TRIP-10 |
NCBI Protein Information: | cdc42-interacting protein 4 |
UniProt Protein Name: | Cdc42-interacting protein 4 |
UniProt Synonym Protein Names: | Protein Felic; Salt tolerant protein; hSTP; Thyroid receptor-interacting protein 10; TR-interacting protein 10; TRIP-10 |
Protein Family: | Cdc42-interacting protein |
UniProt Gene Name: | TRIP10 |
UniProt Entry Name: | CIP4_HUMAN |