TRIM33 Antibody (PACO51182)
- SKU:
- PACO51182
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | TRIM33 Antibody (PACO51182) |
抗体コード: | PACO51182 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA, IHC, IF |
推奨される希釈: | ELISA:1:2000-1:10000, IHC:1:20-1:200, IF:1:50-1:200 |
反応性: | Human |
免疫原: | Recombinant Human E3 ubiquitin-protein ligase TRIM33 protein (1-273AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
![]() | Immunohistochemistry analysis of human brain tissue using PACO51182 at dilution of 1:100. |
![]() | Immunofluorescent analysis of MCF-7 cells using PACO51182 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
バックグラウンド: | Acts as an E3 ubiquitin-protein ligase. Promotes SMAD4 ubiquitination, nuclear exclusion and degradation via the ubiquitin proteasome pathway. According to PubMed:16751102, does not promote a decrease in the level of endogenous SMAD4. May act as a transcriptional repressor. Inhibits the transcriptional response to TGF-beta/BMP signaling cascade. Plays a role in the control of cell proliferation. Its association with SMAD2 and SMAD3 stimulates erythroid differentiation of hematopoietic stem/progenitor (By similarity). Monoubiquitinates SMAD4 and acts as an inhibitor of SMAD4-dependent TGF-beta/BMP signaling cascade (Monoubiquitination of SMAD4 hampers its ability to form a stable complex with activated SMAD2/3 resulting in inhibition of TGF-beta/BMP signaling cascade). |
シノニム: | E3 ubiquitin-protein ligase TRIM33 (EC 2.3.2.27) (Ectodermin homolog) (RET-fused gene 7 protein) (Protein Rfg7) (RING-type E3 ubiquitin transferase TRIM33) (Transcription intermediary factor 1-gamma) (TIF1-gamma) (Tripartite motif-containing protein 33), TRIM33, KIAA1113 RFG7 TIF1G |
UniProt Protein Function: | TIF1G: an atypical protein kinase that functions as a transcriptional repressor. Translocation with RET generates the TRIM33/RET (PTC7) oncogene. The protein is a member of the tripartite motif family. This motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. Two splice variant isoforms have been described. |
UniProt Protein Details: | Protein type:Kinase, protein; Ubiquitin ligase; Ligase; EC 6.3.2.19; Ubiquitin conjugating system; Transcription, coactivator/corepressor; EC 6.3.2.-; Protein kinase, atypical; ATYPICAL group; TIF1 family Chromosomal Location of Human Ortholog: 1p13.1 Cellular Component: intracellular membrane-bound organelle; nucleoplasm; nucleus Molecular Function:protein binding; ubiquitin-protein ligase activity Biological Process: negative regulation of BMP signaling pathway; negative regulation of transcription from RNA polymerase II promoter; protein ubiquitination; regulation of transforming growth factor beta receptor signaling pathway Disease: Thyroid Carcinoma, Papillary |
NCBI Summary: | The protein encoded by this gene is thought to be a transcriptional corepressor. However, molecules that interact with this protein have not yet been identified. The protein is a member of the tripartite motif family. This motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. Three alternatively spliced transcript variants for this gene have been described, however, the full-length nature of one variant has not been determined. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q9UPN9 |
NCBI GenInfo Identifier: | 313104270 |
NCBI Gene ID: | 51592 |
NCBI Accession: | Q9UPN9.3 |
UniProt Secondary Accession: | Q9UPN9,O95855, Q5TG72, Q5TG73, Q5TG74, Q9C017, Q9UJ79 |
UniProt Related Accession: | Q9UPN9 |
Molecular Weight: | 120,541 Da |
NCBI Full Name: | E3 ubiquitin-protein ligase TRIM33 |
NCBI Synonym Full Names: | tripartite motif containing 33 |
NCBI Official Symbol: | TRIM33 |
NCBI Official Synonym Symbols: | ECTO; PTC7; RFG7; TF1G; TIF1G; TIFGAMMA; TIF1GAMMA |
NCBI Protein Information: | E3 ubiquitin-protein ligase TRIM33 |
UniProt Protein Name: | E3 ubiquitin-protein ligase TRIM33 |
UniProt Synonym Protein Names: | Ectodermin homolog; RET-fused gene 7 protein; Protein Rfg7; Transcription intermediary factor 1-gamma; TIF1-gamma; Tripartite motif-containing protein 33 |
Protein Family: | E3 ubiquitin-protein ligase |
UniProt Gene Name: | TRIM33 |
UniProt Entry Name: | TRI33_HUMAN |