UniProt Protein Function: | TRIM22: Interferon-induced antiviral protein involved in cell innate immunity. The antiviral activity could in part be mediated by TRIM22-dependent ubiquitination of viral proteins. Plays a role in restricting the replication of HIV-1, encephalomyocarditis virus (EMCV) and hepatitis B virus (HBV). Acts as a transcriptional repressor of HBV core promoter. May have E3 ubiquitin-protein ligase activity. Belongs to the TRIM/RBCC family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Ubiquitin conjugating system; Ligase; Ubiquitin ligase; EC 6.3.2.-; Transcription, coactivator/corepressor Chromosomal Location of Human Ortholog: 11p15 Cellular Component: cytoplasm; cytosol; nucleoplasm; nucleus Molecular Function:protein binding; protein binding, bridging; protein kinase binding; transcription corepressor activity; transcription factor activity Biological Process: activation of NF-kappaB transcription factor; immune response; positive regulation of autophagy; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of transcription factor activity; regulation of protein localization; regulation of transcription, DNA-dependent; response to virus |
NCBI Summary: | The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to the cytoplasm and its expression is induced by interferon. The protein down-regulates transcription from the HIV-1 LTR promoter region, suggesting that function of this protein may be to mediate interferon's antiviral effects. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010] |
UniProt Code: | Q8IYM9 |
NCBI GenInfo Identifier: | 47606181 |
NCBI Gene ID: | 10346 |
NCBI Accession: | Q8IYM9.1 |
UniProt Secondary Accession: | Q8IYM9,Q05CQ0, Q15521, |
UniProt Related Accession: | Q8IYM9 |
Molecular Weight: | 56,429 Da |
NCBI Full Name: | E3 ubiquitin-protein ligase TRIM22 |
NCBI Synonym Full Names: | tripartite motif containing 22 |
NCBI Official Symbol: | TRIM22 |
NCBI Official Synonym Symbols: | RNF94; STAF50; GPSTAF50 |
NCBI Protein Information: | E3 ubiquitin-protein ligase TRIM22 |
UniProt Protein Name: | E3 ubiquitin-protein ligase TRIM22 |
UniProt Synonym Protein Names: | 50 kDa-stimulated trans-acting factor; RING finger protein 94; Staf-50; Tripartite motif-containing protein 22 |
Protein Family: | E3 ubiquitin-protein ligase |
UniProt Gene Name: | TRIM22 |
UniProt Entry Name: | TRI22_HUMAN |