TRIB2 Antibody, Biotin conjugated (PACO53505)
- SKU:
- PACO53505
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- Biotin
Frequently bought together:
Description
抗体名: | TRIB2 Antibody, Biotin conjugated (PACO53505) |
抗体コード: | PACO53505 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Tribbles homolog 2 protein (204-337AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Biotin |
バックグラウンド: | Interacts with MAPK kinases and regulates activation of MAP kinases. Does not display kinase activity (By similarity). |
シノニム: | Tribbles homolog 2 (TRB-2), TRIB2, TRB2 |
UniProt Protein Function: | TRB2: Interacts with MAPK kinases and regulates activation of MAP kinases. Does not display kinase activity. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. Tribbles subfamily. |
UniProt Protein Details: | Protein type:CAMK group; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Trbl family Chromosomal Location of Human Ortholog: 2p24.3 Cellular Component: cytoplasm; nucleus Molecular Function:mitogen-activated protein kinase kinase binding; nucleotide binding; protein kinase activity; transcription factor binding; ubiquitin protein ligase binding; ubiquitin-protein ligase regulator activity Biological Process: negative regulation of fat cell differentiation; negative regulation of interleukin-10 biosynthetic process; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; protein amino acid phosphorylation; regulation of MAP kinase activity |
NCBI Summary: | This gene encodes one of three members of the Tribbles family. The Tribbles members share a Trb domain, which is homologous to protein serine-threonine kinases, but lacks the active site lysine and probably lacks a catalytic function. The Tribbles proteins interact and modulate the activity of signal transduction pathways in a number of physiological and pathological processes. This Tribbles member induces apoptosis of cells mainly of the hematopoietic origin. It has been identified as a protein up-regulated by inflammatory stimuli in myeloid (THP-1) cells, and also as an oncogene that inactivates the transcription factor C/EBPalpha (CCAAT/enhancer-binding protein alpha) and causes acute myelogenous leukemia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2009] |
UniProt Code: | Q92519 |
NCBI GenInfo Identifier: | 74762638 |
NCBI Gene ID: | 28951 |
NCBI Accession: | Q92519.1 |
UniProt Secondary Accession: | Q92519,B2R851, D6W510, |
UniProt Related Accession: | Q92519 |
Molecular Weight: | 39kDa |
NCBI Full Name: | Tribbles homolog 2 |
NCBI Synonym Full Names: | tribbles pseudokinase 2 |
NCBI Official Symbol: | TRIB2 |
NCBI Official Synonym Symbols: | C5FW; TRB2; GS3955 |
NCBI Protein Information: | tribbles homolog 2 |
UniProt Protein Name: | Tribbles homolog 2 |
Protein Family: | Tribbles |
UniProt Gene Name: | TRIB2 |