TREM2 Antibody (PACO55030)
- SKU:
- PACO55030
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | TREM2 Antibody (PACO55030) |
抗体コード: | PACO55030 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA, IHC, IF |
推奨される希釈: | ELISA:1:2000-1:10000, IHC:1:20-1:200, IF:1:20-1:200 |
反応性: | Human |
免疫原: | Recombinant Human Triggering receptor expressed on myeloid cells 2 protein (19-174AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
![]() | Immunohistochemistry of paraffin-embedded human melanoma using PACO55030 at dilution of 1:100. |
![]() | Immunofluorescence staining of HepG2 cells with PACO55030 at 1:166, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
バックグラウンド: | May have a role in chronic inflammations and may stimulate production of constitutive rather than inflammatory chemokines and cytokines. Forms a receptor signaling complex with TYROBP and triggers activation of the immune responses in macrophages and dendritic cells. |
シノニム: | Triggering receptor expressed on myeloid cells 2 (TREM-2) (Triggering receptor expressed on monocytes 2), TREM2 |
UniProt Protein Function: | TREM2: May have a role in chronic inflammations and may stimulate production of constitutive rather than inflammatory chemokines and cytokines. Forms a receptor signaling complex with TYROBP and triggers activation of the immune responses in macrophages and dendritic cells. Defects in TREM2 are a cause of polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL); also known as presenile dementia with bone cysts or Nasu-Hakola disease (NHD). PLOSL is a recessively inherited disease characterized by a combination of psychotic symptoms rapidly progressing to presenile dementia and bone cysts restricted to wrists and ankles. PLOSL has a global distribution, although most of the patients have been diagnosed in Finland and Japan, with an estimated population prevalence of 2x10(-6) in the Finns. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 6p21.1 Cellular Component: integral to membrane; intracellular membrane-bound organelle; plasma membrane Molecular Function:receptor activity Biological Process: humoral immune response; innate immune response; positive regulation of antigen processing and presentation of peptide antigen via MHC class II; positive regulation of calcium-mediated signaling; positive regulation of peptidyl-tyrosine phosphorylation; regulation of immune response Disease: Polycystic Lipomembranous Osteodysplasia With Sclerosing Leukoencephalopathy |
NCBI Summary: | This gene encodes a membrane protein that forms a receptor signaling complex with the TYRO protein tyrosine kinase binding protein. The encoded protein functions in immune response and may be involved in chronic inflammation by triggering the production of constitutive inflammatory cytokines. Defects in this gene are a cause of polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2012] |
UniProt Code: | Q9NZC2 |
NCBI GenInfo Identifier: | 50401689 |
NCBI Gene ID: | 54209 |
NCBI Accession: | Q9NZC2.1 |
UniProt Secondary Accession: | Q9NZC2,Q8N5H8, Q8WYN6, |
UniProt Related Accession: | Q9NZC2 |
Molecular Weight: | 25kDa |
NCBI Full Name: | Triggering receptor expressed on myeloid cells 2 |
NCBI Synonym Full Names: | triggering receptor expressed on myeloid cells 2 |
NCBI Official Symbol: | TREM2 |
NCBI Official Synonym Symbols: | TREM-2; Trem2a; Trem2b; Trem2c |
NCBI Protein Information: | triggering receptor expressed on myeloid cells 2 |
UniProt Protein Name: | Triggering receptor expressed on myeloid cells 2 |
UniProt Synonym Protein Names: | Triggering receptor expressed on monocytes 2 |
Protein Family: | Triggering receptor expressed on myeloid cells |
UniProt Gene Name: | TREM2 |
Antibodies | ELISA Kits |
Anti-TREM2 Antibody (CAB10482) | Human TREM2 / Triggering receptor expressed on myeloid cells 3 ELISA Kit |
Human Triggering receptor expressed on myeloid cells 2 (TREM2) ELISA Kit |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |