TRADD Antibody, Biotin conjugated (PACO50585)
- SKU:
- PACO50585
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- Biotin
Description
抗体名: | TRADD Antibody, Biotin conjugated (PACO50585) |
抗体コード: | PACO50585 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Tumor necrosis factor receptor type 1-associated DEATH domain protein (1-312AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Biotin |
バックグラウンド: | The nuclear form acts as a tumor suppressor by preventing ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A by TRIP12: acts by interacting with TRIP12, leading to disrupt interaction between TRIP12 and isoform p19ARF/ARF of CDKN2A (By similarity). Adapter molecule for TNFRSF1A/TNFR1 that specifically associates with the cytoplasmic domain of activated TNFRSF1A/TNFR1 mediating its interaction with FADD. Overexpression of TRADD leads to two major TNF-induced responses, apoptosis and activation of NF-kappa-B. |
シノニム: | Tumor necrosis factor receptor type 1-associated DEATH domain protein (TNFR1-associated DEATH domain protein) (TNFRSF1A-associated via death domain), TRADD |
UniProt Protein Function: | TRADD: Adapter molecule for TNFRSF1A/TNFR1 that specifically associates with the cytoplasmic domain of activated TNFRSF1A/TNFR1 mediating its interaction with FADD. Overexpression of TRADD leads to two major TNF-induced responses, apoptosis and activation of NF-kappa-B. Heterodimer with TNFRSF1A/TNFR1. Interacts with DAB2IP, FADD, HIPK2, KRT14, KRT16, KRT17, KRT18, RIPK1, SQSTM1, TRAF1, TRAF2 and TRPC4AP. Found in all examined tissues. |
UniProt Protein Details: | Protein type:Apoptosis; Adaptor/scaffold Chromosomal Location of Human Ortholog: 16q22 Cellular Component: cytoskeleton; cytoplasm; nucleus; cytosol; receptor complex; lipid raft Molecular Function:identical protein binding; protein binding; signal transducer activity; protein complex binding; kinase binding; tumor necrosis factor receptor binding; molecular adaptor activity Biological Process: positive regulation of hair follicle development; caspase activation; positive regulation of I-kappaB kinase/NF-kappaB cascade; tumor necrosis factor-mediated signaling pathway; induction of apoptosis via death domain receptors; apoptosis; protein heterooligomerization; positive regulation of apoptosis; signal transduction; activation of NF-kappaB transcription factor |
NCBI Summary: | The protein encoded by this gene is a death domain containing adaptor molecule that interacts with TNFRSF1A/TNFR1 and mediates programmed cell death signaling and NF-kappaB activation. This protein binds adaptor protein TRAF2, reduces the recruitment of inhibitor-of-apoptosis proteins (IAPs) by TRAF2, and thus suppresses TRAF2 mediated apoptosis. This protein can also interact with receptor TNFRSF6/FAS and adaptor protein FADD/MORT1, and is involved in the Fas-induced cell death pathway. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q15628 |
NCBI GenInfo Identifier: | 6094511 |
NCBI Gene ID: | 8717 |
NCBI Accession: | Q15628.2 |
UniProt Secondary Accession: | Q15628,Q52NZ1, B2RDS3, B3KQZ9, |
UniProt Related Accession: | Q15628 |
Molecular Weight: | 312 |
NCBI Full Name: | Tumor necrosis factor receptor type 1-associated DEATH domain protein |
NCBI Synonym Full Names: | TNFRSF1A-associated via death domain |
NCBI Official Symbol: | TRADD |
NCBI Official Synonym Symbols: | Hs.89862 |
NCBI Protein Information: | tumor necrosis factor receptor type 1-associated DEATH domain protein; TNFR1-associated death domain protein; tumor necrosis factor receptor-1-associated protein; tumor necrosis factor receptor type 1 associated death domain protein |
UniProt Protein Name: | Tumor necrosis factor receptor type 1-associated DEATH domain protein |
UniProt Synonym Protein Names: | TNFRSF1A-associated via death domain |
Protein Family: | Tumor necrosis factor receptor type 1-associated DEATH domain protein |
UniProt Gene Name: | TRADD |
UniProt Entry Name: | TRADD_HUMAN |