TRABD2B Antibody, Biotin conjugated (PACO63054)
- SKU:
- PACO63054
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- Biotin
Frequently bought together:
Description
抗体名: | TRABD2B Antibody, Biotin conjugated (PACO63054) |
抗体コード: | PACO63054 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Metalloprotease TIKI2 protein (195-405AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | Antigen Affinity Purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Biotin |
バックグラウンド: | Metalloprotease that acts as a negative regulator of the Wnt signaling pathway by mediating the cleavage of the 8 N-terminal residues of a subset of Wnt proteins. Following cleavage, Wnt proteins become oxidized and form large disulfide-bond oligomers, leading to their inactivation. Able to cleave WNT3A, WNT5, but not WNT11. Required for head formation. |
シノニム: | Metalloprotease TIKI2 (EC 3.4) (Heart, kidney and adipose-enriched transmembrane protein homolog) (TRAB domain-containing protein 2B), TRABD2B, HKAT TIKI2 |
UniProt Protein Function: | LOC388630: Metalloprotease that acts as a negative regulator of the Wnt signaling pathway by mediating the cleavage of the 8 N- terminal residues of a subset of Wnt proteins. Following cleavage, Wnt proteins become oxidized and form large disulfide-bond oligomers, leading to their inactivation. Able to cleave WNT3A, WNT5, but not WNT11. Required for head formation. Belongs to the TIKI family. |
UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 1p33 Cellular Component: integral to plasma membrane Molecular Function:Wnt-protein binding; protein binding; metal ion binding; metalloendopeptidase activity Biological Process: Wnt receptor signaling pathway; negative regulation of Wnt receptor signaling pathway; protein amino acid oxidation; metabolic process; proteolysis |
UniProt Code: | A6NFA1 |
NCBI GenInfo Identifier: | 303228327 |
NCBI Gene ID: | 388630 |
NCBI Accession: | NP_001181915.1 |
UniProt Secondary Accession: | A6NFA1,I6U4Y0, |
UniProt Related Accession: | A6NFA1 |
Molecular Weight: | 57,421 Da |
NCBI Full Name: | metalloprotease TIKI2 |
NCBI Synonym Full Names: | TraB domain containing 2B |
NCBI Official Symbol: | TRABD2B |
NCBI Official Synonym Symbols: | TIKI2 |
NCBI Protein Information: | metalloprotease TIKI2 |
UniProt Protein Name: | Metalloprotease TIKI2 |
UniProt Synonym Protein Names: | Heart, kidney and adipose-enriched transmembrane protein homolog; TRAB domain-containing protein 2B |
Protein Family: | Metalloprotease |
UniProt Gene Name: | TRABD2B |
UniProt Entry Name: | TIKI2_HUMAN |