TPX2 Antibody, HRP conjugated (PACO56239)
- SKU:
- PACO56239
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- HRP
Frequently bought together:
Description
抗体名: | TPX2 Antibody, HRP conjugated (PACO56239) |
抗体コード: | PACO56239 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Targeting protein for Xklp2 protein (160-320AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | HRP |
バックグラウンド: | Spindle assembly factor required for normal assembly of mitotic spindles. Required for normal assembly of microtubules during apoptosis. Required for chromatin and/or kinetochore dependent microtubule nucleation. Mediates AURKA localization to spindle microtubules. Activates AURKA by promoting its autophosphorylation at 'Thr-288' and protects this residue against dephosphorylation. TPX2 is inactivated upon binding to importin-α. At the onset of mitosis, GOLGA2 interacts with importin-alpha, liberating TPX2 from importin-alpha, allowing TPX2 to activates AURKA kinase and stimulates local microtubule nucleation. |
シノニム: | Targeting protein for Xklp2 (Differentially expressed in cancerous and non-cancerous lung cells 2) (DIL-2) (Hepatocellular carcinoma-associated antigen 519) (Hepatocellular carcinoma-associated antigen 90) (Protein fls353) (Restricted expression proliferation-associated protein 100) (p100), TPX2, C20orf1 C20orf2 DIL2 HCA519 |
UniProt Protein Function: | Spindle assembly factor required for normal assembly of mitotic spindles. Required for normal assembly of microtubules during apoptosis. Required for chromatin and/or kinetochore dependent microtubule nucleation. Mediates AURKA localization to spindle microtubules (PubMed:18663142, PubMed:19208764). Activates AURKA by promoting its autophosphorylation at 'Thr-288' and protects this residue against dephosphorylation (PubMed:18663142, PubMed:19208764). TPX2 is inactivated upon binding to importin-alpha (PubMed:26165940). At the onset of mitosis, GOLGA2 interacts with importin-alpha, liberating TPX2 from importin-alpha, allowing TPX2 to activates AURKA kinase and stimulates local microtubule nucleation (PubMed:26165940). |
UniProt Code: | Q9ULW0 |
NCBI GenInfo Identifier: | 13124096 |
NCBI Gene ID: | 22974 |
NCBI Accession: | Q9ULW0.2 |
UniProt Secondary Accession: | Q9ULW0,Q96RR5, Q9H1R4, Q9NRA3, Q9UFN9, Q9UL00, Q9Y2M1 |
UniProt Related Accession: | Q9ULW0 |
Molecular Weight: | 89,393 Da |
NCBI Full Name: | Targeting protein for Xklp2 |
NCBI Synonym Full Names: | TPX2, microtubule nucleation factor |
NCBI Official Symbol: | TPX2 |
NCBI Official Synonym Symbols: | DIL2; p100; DIL-2; HCTP4; FLS353; HCA519; REPP86; C20orf1; C20orf2; GD:C20orf1 |
NCBI Protein Information: | targeting protein for Xklp2 |
UniProt Protein Name: | Targeting protein for Xklp2 |
UniProt Synonym Protein Names: | Differentially expressed in cancerous and non-cancerous lung cells 2; DIL-2; Hepatocellular carcinoma-associated antigen 519; Hepatocellular carcinoma-associated antigen 90; Protein fls353; Restricted expression proliferation-associated protein 100; p100 |
Protein Family: | Targeting protein |
UniProt Gene Name: | TPX2 |
UniProt Entry Name: | TPX2_HUMAN |