TPMT Antibody (PACO12867)
- SKU:
- PACO12867
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | TPMT Antibody (PACO12867) |
抗体コード: | PACO12867 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IHC |
推奨される希釈: | |
反応性: | Human, Mouse, Rat |
免疫原: | Human TPMT |
憲法: | Liquid |
ストレージバッファ: | PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles. |
精製方法: | Antigen Affinity Purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
シノニム: | thiopurine S-methyltransferase; |
UniProt Protein Function: | TPMT: Catalyzes the S-methylation of thiopurine drugs such as 6-mercaptopurine. Defects in TPMT are the cause of thiopurine S- methyltransferase deficiency (TPMT deficiency). TPMT is an enzyme involved in the normal metabolic inactivation of thiopurine drugs. These drugs are generally used as immunosupressants or cytotoxic drugs and are prescribed for a variety of clinical conditions including leukemia, autoimmune disease and organ transplantation. Patients with intermediate or no TPMT activity are at risk of toxicity after receiving standard doses of thiopurine drugs and it is shown that inter-individual differences in response to these drugs are largely determined by genetic variation at the TPMT locus. Belongs to the methyltransferase superfamily. TPMT family. |
UniProt Protein Details: | Protein type:Xenobiotic Metabolism - drug metabolism - other enzymes; EC 2.1.1.67; Methyltransferase Chromosomal Location of Human Ortholog: 6p22.3 Cellular Component: cytosol Molecular Function:thiopurine S-methyltransferase activity Biological Process: methylation; xenobiotic metabolic process; nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Disease: Thiopurine S-methyltransferase Deficiency |
NCBI Summary: | This gene encodes the enzyme that metabolizes thiopurine drugs via S-adenosyl-L-methionine as the S-methyl donor and S-adenosyl-L-homocysteine as a byproduct. Thiopurine drugs such as 6-mercaptopurine are used as chemotherapeutic agents. Genetic polymorphisms that affect this enzymatic activity are correlated with variations in sensitivity and toxicity to such drugs within individuals, causing thiopurine S-methyltransferase deficiency. Related pseudogenes have been identified on chromosomes 3, 18 and X. [provided by RefSeq, Aug 2014] |
UniProt Code: | P51580 |
NCBI GenInfo Identifier: | 1730006 |
NCBI Gene ID: | 7172 |
NCBI Accession: | P51580.1 |
UniProt Secondary Accession: | P51580,O14806, O15423, O15424, O15425, O15426, O15515 O15548, O43213, Q5VUK6, Q9UBE6, Q9UBT8, |
UniProt Related Accession: | P51580 |
Molecular Weight: | 245 |
NCBI Full Name: | Thiopurine S-methyltransferase |
NCBI Synonym Full Names: | thiopurine S-methyltransferase |
NCBI Official Symbol: | TPMT |
NCBI Protein Information: | thiopurine S-methyltransferase; S-adenosyl-L-methionine:thiopurine S-methyltransferase |
UniProt Protein Name: | Thiopurine S-methyltransferase |
UniProt Synonym Protein Names: | Thiopurine methyltransferase |
UniProt Gene Name: | TPMT |
UniProt Entry Name: | TPMT_HUMAN |