TPM3 Antibody (PACO50070)
- SKU:
- PACO50070
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | TPM3 Antibody (PACO50070) |
抗体コード: | PACO50070 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA, IHC, IF |
推奨される希釈: | ELISA:1:2000-1:10000, IHC:1:20-1:200, IF:1:50-1:200 |
反応性: | Human |
免疫原: | Recombinant Human Tropomyosin alpha-3 chain protein (18-224AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
![]() | Immunohistochemistry of paraffin-embedded human liver cancer using PACO50070 at dilution of 1:100. |
![]() | Immunofluorescent analysis of HepG2 cells using PACO50070 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
![]() | Immunohistochemistry of paraffin-embedded human colon cancer using PACO50070 at dilution of 1:100. |
バックグラウンド: | Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. |
シノニム: | Tropomyosin alpha-3 chain (Gamma-tropomyosin) (Tropomyosin-3) (Tropomyosin-5) (hTM5), TPM3 |
UniProt Protein Function: | TPM3: a cytoskeletal protein that binds to actin filaments in muscle and nonmuscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. Defects in TPM3 are a cause of nemaline myopathy type 1 (NEM1). Three alternatively spliced isoforms have been described. |
UniProt Protein Details: | Protein type:Contractile; Cytoskeletal; Oncoprotein; Actin-binding; Motor; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 1q21.2 Cellular Component: cortical cytoskeleton; filamentous actin; cytoskeleton; growth cone; stress fiber; podosome; cytosol; muscle thin filament tropomyosin; cleavage furrow Molecular Function:actin binding Biological Process: muscle contraction; cell motility; muscle filament sliding Disease: Nemaline Myopathy 1; Myopathy, Congenital, With Fiber-type Disproportion |
NCBI Summary: | This gene encodes a member of the tropomyosin family of actin-binding proteins. Tropomyosins are dimers of coiled-coil proteins that provide stability to actin filaments and regulate access of other actin-binding proteins. Mutations in this gene result in autosomal dominant nemaline myopathy and other muscle disorders. This locus is involved in translocations with other loci, including anaplastic lymphoma receptor tyrosine kinase (ALK) and neurotrophic tyrosine kinase receptor type 1 (NTRK1), which result in the formation of fusion proteins that act as oncogenes. There are numerous pseudogenes for this gene on different chromosomes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013] |
UniProt Code: | P06753 |
NCBI GenInfo Identifier: | 519668659 |
NCBI Gene ID: | 7170 |
NCBI Accession: | P06753.2 |
UniProt Secondary Accession: | P06753,P12324, Q2QD06, Q5VU58, Q5VU63, Q5VU66, Q5VU71 Q5VU72, Q8TCG3, Q969Q2, Q9NQH8, D3DV71, |
UniProt Related Accession: | P06753 |
Molecular Weight: | |
NCBI Full Name: | Tropomyosin alpha-3 chain |
NCBI Synonym Full Names: | tropomyosin 3 |
NCBI Official Symbol: | TPM3 |
NCBI Official Synonym Symbols: | TM3; TM5; TRK; CFTD; NEM1; TM-5; TM30; CAPM1; TM30nm; TPMsk3; hscp30; HEL-189; HEL-S-82p; OK/SW-cl.5 |
NCBI Protein Information: | tropomyosin alpha-3 chain; tropomyosin-5; tropomyosin gamma; cytoskeletal tropomyosin TM30; epididymis luminal protein 189; alpha-tropomyosin, slow skeletal; heat-stable cytoskeletal protein 30 kDa; epididymis secretory sperm binding protein Li 82p |
UniProt Protein Name: | Tropomyosin alpha-3 chain |
UniProt Synonym Protein Names: | Gamma-tropomyosin; Tropomyosin-3; Tropomyosin-5; hTM5 |
Protein Family: | Tropomyosin |
UniProt Gene Name: | TPM3 |
UniProt Entry Name: | TPM3_HUMAN |