TOP2B Antibody (PACO05231)
- SKU:
- PACO05231
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | TOP2B Antibody (PACO05231) |
抗体コード: | PACO05231 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IHC |
推奨される希釈: | ELISA:1:20000, WB:1:500-1:2000, IHC:1:100-1:300 |
反応性: | Human, Mouse |
免疫原: | Synthesized peptide derived from the N-terminal region of human Topo II β . |
憲法: | Liquid |
ストレージバッファ: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
精製方法: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
シノニム: | TOP2B; DNA topoisomerase 2-β; DNA topoisomerase II; β isozyme |
UniProt Protein Function: | Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks. |
NCBI Summary: | This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, beta, is localized to chromosome 3 and the alpha form is localized to chromosome 17. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2016] |
UniProt Code: | Q02880 |
NCBI GenInfo Identifier: | 339810 |
NCBI Gene ID: | 7155 |
NCBI Accession: | AAA61210.1 |
UniProt Secondary Accession: | Q02880,Q13600, Q9UMG8, Q9UQP8, |
UniProt Related Accession: | Q02880 |
Molecular Weight: | 182,663 Da |
NCBI Full Name: | topoisomerase II, partial |
NCBI Synonym Full Names: | DNA topoisomerase II beta |
NCBI Official Symbol: | TOP2B |
NCBI Official Synonym Symbols: | TOPIIB; top2beta |
NCBI Protein Information: | DNA topoisomerase 2-beta |
UniProt Protein Name: | DNA topoisomerase 2-beta |
UniProt Synonym Protein Names: | DNA topoisomerase II, beta isozyme |
Protein Family: | DNA topoisomerase |
UniProt Gene Name: | TOP2B |